Seroatlas · Human Serome Atlas

DPPA2

Developmental pluripotency-associated protein 2

Also known as: CT100, DPPA2_HUMAN, PESCRG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7J5
Gene: DPPA2
Ensembl: ENSG00000163530
Chromosome: 3
Canonical length: 298 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Predicted to be involved in system development. Predicted to act upstream of or within several processes, including epigenetic regulation of gene expression; lung-associated mesenchyme development; and positive regulation of stem cell proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q7Z7J5|DPPA2
     1  MSDANLDSSK KNFLEGEVDD EESVILTLVP VKDDANMEQM EPSVSSTSDV KLEKPKKYNP
    61  GHLLQTNEQF TAPQKARCKI PALPLPTILP PINKVCRDTL RDWCQQLGLS TNGKKIEVYL
   121  RLHRHAYPEQ RQDMPEMSQE TRLQRCSRKR KAVTKRARLQ RSYEMNERAE ETNTVEVITS
   181  APGAMLASWA RIAARAVQPK ALNSCSIPVS VEAFLMQASG VRWCVVHGRL LSADTKGWVR
   241  LQFHAGQAWV PTTHRRMISL FLLPACIFPS PGIEDNMLCP DCAKRNKKMM KRLMTVEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPPA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

testis: 3.1 nTPM
placenta: 0.3 nTPM
kidney: 0.1 nTPM
thymus: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

undifferentiated spermatogonia: 32 nCPM
extravillous trophoblasts: 17 nCPM
migrating cytotrophoblasts: 5.5 nCPM
cytotrophoblasts: 4.5 nCPM
retinal ganglion cells: 3.9 nCPM
smooth muscle cells: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
choroid plexus: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DPPA2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Premature ovarian failure

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

system development

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPPA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DPPA4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPPA2 as an antibody target. Whether an autoantibody or antibody against DPPA2 could matter depends on whether native DPPA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPPA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPPA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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