Seroatlas · Human Serome Atlas

DPF3

Zinc finger protein DPF3

Also known as: BAF45c, cer-d4, Cerd4, DPF3_HUMAN, FLJ14079, SMARCG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92784
Gene: DPF3
Ensembl: ENSG00000205683
Chromosome: 14
Canonical length: 378 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q92784|DPF3
     1  MATVIHNPLK ALGDQFYKEA IEHCRSYNSR LCAERSVRLP FLDSQTGVAQ NNCYIWMEKR
    61  HRGPGLAPGQ LYTYPARCWR KKRRLHPPED PKLRLLEIKP EVELPLKKDG FTSESTTLEA
   121  LLRGEGVEKK VDAREEESIQ EIQRVLENDE NVEEGNEEED LEEDIPKRKN RTRGRARGSA
   181  GGRRRHDAAS QEDHDKPYVC DICGKRYKNR PGLSYHYAHT HLASEEGDEA QDQETRSPPN
   241  HRNENHRPQK GPDGTVIPNN YCDFCLGGSN MNKKSGRPEE LVSCADCGRS GHPTCLQFTL
   301  NMTEAVKTYK WQCIECKSCI LCGTSENDDQ LLFCDDCDRG YHMYCLNPPV AEPPEGSWSC
   361  HLCWELLKEK ASAFGCQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 16 nTPM
retina: 4.8 nTPM
heart muscle: 3.9 nTPM
skeletal muscle: 3.3 nTPM
hippocampal formation: 2.3 nTPM
ovary: 1.6 nTPM

Single-cell type

myonuclei: 958 nCPM
cardiomyocytes: 739 nCPM
cone photoreceptor cells: 725 nCPM
rod photoreceptor cells: 473 nCPM
retinal amacrine cells: 236 nCPM
astrocytes: 200 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 28 nTPM
pons: 16 nTPM
hippocampal formation: 13 nTPM
medulla oblongata: 10 nTPM
cerebral cortex: 6.8 nTPM
basal ganglia: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.02
gnomAD missense Z: 1.15
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPF3 as an antibody target. Whether an autoantibody or antibody against DPF3 could matter depends on whether native DPF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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