Seroatlas · Human Serome Atlas

DNAL4

Dynein axonemal light chain 4

Also known as: dJ327J16, DNAL4_HUMAN, PIG27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O96015
Gene
DNAL4
Ensembl
ENSG00000100246
Chromosome
22
Canonical length
105 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Primary cilium transition zone,Centrosome,Basal body,Cytosol,Acrosome,Equatorial segment,Perinuclear theca,Calyx,Principal piece

OverviewNCBI Gene

This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>O96015|DNAL4
     1  MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN ESAAKMIKET
    61  MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC VWKCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • testis: 64 nTPM
  • amygdala: 37 nTPM
  • cerebral cortex: 35 nTPM
  • basal ganglia: 34 nTPM
  • fallopian tube: 33 nTPM
  • hippocampal formation: 31 nTPM

Single-cell type

  • late spermatids: 246 nCPM
  • early spermatids: 35 nCPM
  • late primary spermatocytes: 6.5 nCPM
  • platelets: 4.2 nCPM
  • fallopian tube ciliated cells: 3 nCPM
  • endometrial ciliated cells: 1.9 nCPM

Immune cell

  • NK-cell: 16 nTPM
  • neutrophil: 15 nTPM
  • basophil: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • plasmacytoid DC: 13 nTPM
  • eosinophil: 12 nTPM

Brain region

  • basal ganglia: 36 nTPM
  • cerebral cortex: 34 nTPM
  • hippocampal formation: 30 nTPM
  • amygdala: 30 nTPM
  • hypothalamus: 29 nTPM
  • thalamus: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAL4.

Disease | AllUniProt

Conditions DNAL4 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 19 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Mirror movements 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAL4 as an antibody target. Whether an autoantibody or antibody against DNAL4 could matter depends on whether native DNAL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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