Seroatlas · Human Serome Atlas

DNAJC5G

DnaJ homolog subfamily C member 5G

Also known as: CSP-gamma, DNJ5G_HUMAN, FLJ40417

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N7S2
Gene
DNAJC5G
Ensembl
ENSG00000163793
Chromosome
2
Canonical length
189 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q8N7S2|DNAJC5G
     1  MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY HLGRKLALRY
    61  HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL GIYLYDHFGE EGVRYYFILN
   121  SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR
   181  SEENSEDDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC5G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 44 nTPM
  • testis: 21 nTPM
  • cerebral cortex: 2.1 nTPM
  • heart muscle: 1.2 nTPM
  • adrenal gland: 0.7 nTPM
  • amygdala: 0.4 nTPM

Single-cell type

  • late primary spermatocytes: 184 nCPM
  • epididymal principal cells: 180 nCPM
  • early primary spermatocytes: 137 nCPM
  • late spermatids: 122 nCPM
  • early spermatids: 61 nCPM
  • sertoli cells: 45 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • cerebral cortex: 10 nTPM
  • hippocampal formation: 6.2 nTPM
  • amygdala: 5.4 nTPM
  • white matter: 5.4 nTPM
  • medulla oblongata: 3.9 nTPM
  • basal ganglia: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC5G as an antibody target. Whether an autoantibody or antibody against DNAJC5G could matter depends on whether native DNAJC5G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC5G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC5G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAJC5G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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