Seroatlas · Human Serome Atlas

DNAJC18

DnaJ homolog subfamily C member 18

Also known as: DJC18_HUMAN, MGC29463

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H819
Gene: DNAJC18
Ensembl: ENSG00000170464
Chromosome: 5
Canonical length: 358 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cell Junctions,Cytosol

OverviewNCBI Gene

Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q9H819|DNAJC18
     1  MAATLGSGER WTEAYIDAVR RNKYPEDTPP ESHDPCGCCN CMKAQKEKKS ENEWTQTRQG
    61  EGNSTYSEEQ LLGVQRIKKC RNYYEILGVS RDASDEELKK AYRKLALKFH PDKNCAPGAT
   121  DAFKAIGNAF AVLSNPDKRL RYDEYGDEQV TFTAPRARPY NYYRDFEADI TPEELFNVFF
   181  GGHFPTGNIH MFSNVTDDTY YYRRRHRHER TQTQKEEEEE KPQTTYSAFI QLLPVLVIVI
   241  ISVITQLLAT NPPYSLFYKS TLGYTISRET QNLQVPYFVD KNFDKAYRGA SLHDLEKTIE
   301  KDYIDYIQTS CWKEKQQKSE LTNLAGLYRD ERLKQKAESL KLENCEKLSK LIGLRRGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

testis: 74 nTPM
cerebral cortex: 15 nTPM
cerebellum: 15 nTPM
spinal cord: 14 nTPM
basal ganglia: 13 nTPM
midbrain: 13 nTPM

Single-cell type

late spermatids: 1,922 nCPM
early spermatids: 503 nCPM
late primary spermatocytes: 216 nCPM
brain inhibitory neurons: 48 nCPM
brain excitatory neurons: 42 nCPM
other brain neurons: 41 nCPM

Immune cell

T-reg: 1.7 nTPM
NK-cell: 1.4 nTPM
memory CD8 T-cell: 0.9 nTPM
naive B-cell: 0.9 nTPM
memory B-cell: 0.8 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

pons: 19 nTPM
cerebral cortex: 19 nTPM
hypothalamus: 19 nTPM
white matter: 18 nTPM
cerebellum: 18 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC18 as an antibody target. Whether an autoantibody or antibody against DNAJC18 could matter depends on whether native DNAJC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...