Seroatlas · Human Serome Atlas

DNAJB9

DnaJ homolog subfamily B member 9

Also known as: DNJB9_HUMAN, MDG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBS3
Gene: DNAJB9
Ensembl: ENSG00000128590
Chromosome: 7
Canonical length: 223 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q9UBS3|DNAJB9
     1  MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS
    61  PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ RGSGSSFEQS FNFNFDDLFK
   121  DFGFFGQNQN TGSKKRFENH FQTRQDGGSS RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS
   181  GFDSTNQHTV QTENRFHGSS KHCRTVTQRR GNMVTTYTDC SGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

liver: 97 nTPM
pancreas: 77 nTPM
thyroid gland: 73 nTPM
epididymis: 59 nTPM
kidney: 59 nTPM
adrenal gland: 55 nTPM

Single-cell type

syncytiotrophoblasts: 828 nCPM
plasma cells: 398 nCPM
early spermatids: 391 nCPM
epididymal principal cells: 332 nCPM
epididymal efferent duct absorptive cells: 318 nCPM
late primary spermatocytes: 292 nCPM

Immune cell

plasmacytoid DC: 78 nTPM
basophil: 76 nTPM
MAIT T-cell: 59 nTPM
memory CD4 T-cell: 36 nTPM
gdT-cell: 34 nTPM
memory CD8 T-cell: 34 nTPM

Brain region

choroid plexus: 40 nTPM
hypothalamus: 33 nTPM
midbrain: 28 nTPM
pons: 27 nTPM
white matter: 25 nTPM
spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.37
gnomAD missense Z: -0.46
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DnaJ domain
DnaJ domain, conserved site
Chaperone J-domain superfamily
DnaJ domain
Hsp70 co-chaperone J-domain-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJB9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJB9 as an antibody target. Whether an autoantibody or antibody against DNAJB9 could matter depends on whether native DNAJB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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