Seroatlas · Human Serome Atlas

DLGAP3

Disks large-associated protein 3

Also known as: DAP3, DLGP3_HUMAN, SAPAP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95886
Gene
DLGAP3
Ensembl
ENSG00000116544
Chromosome
1
Canonical length
979 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Plasma membrane,Midbody

OverviewNCBI Gene

Predicted to enable PDZ domain binding activity; molecular adaptor activity; and scaffold protein binding activity. Predicted to be involved in modulation of chemical synaptic transmission and protein-containing complex assembly. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

979 residues, UniProt reviewed canonical sequence.

>O95886|DLGAP3
     1  MRGYHGDRGS HPRPARFADQ QHMDVGPAAR APYLLGSREA FSTEPRFCAP RAGLGHISPE
    61  GPLSLSEGPS VGPEGGPAGA GVGGGSSTFP RMYPGQGPFD TCEDCVGHPQ GKGAPRLPPT
   121  LLDQFEKQLP VQQDGFHTLP YQRGPAGAGP GPAPGTGTAP EPRSESPSRI RHLVHSVQKL
   181  FAKSHSLEAP GKRDYNGPKA EGRGGSGGDS YPGPGSGGPH TSHHHHHHHH HHHHQSRHGK
   241  RSKSKDRKGD GRHQAKSTGW WSSDDNLDSD SGFLAGGRPP GEPGGPFCLE GPDGSYRDLS
   301  FKGRSGGSEG RCLACTGMSM SLDGQSVKRS AWHTMMVSQG RDGYPGAGPG KGLLGPETKA
   361  KARTYHYLQV PQDDWGGYPT GGKDGEIPCR RMRSGSYIKA MGDEESGDSD GSPKTSPKAV
   421  ARRFTTRRSS SVDQARINCC VPPRIHPRSS IPGYSRSLTT GQLSDELNQQ LEAVCGSVFG
   481  ELESQAVDAL DLPGCFRMRS HSYLRAIQAG CSQDDDCLPL LATPAAVSGR PGSSFNFRKA
   541  PPPIPPGSQA PPRISITAQS STDSAHESFT AAEGPARRCS SADGLDGPAM GARTLELAPV
   601  PPRASPKPPT LIIKTIPGRE ELRSLARQRK WRPSIGVQVE TISDSDTENR SRREFHSIGV
   661  QVEEDKRRAR FKRSNSVTAG VQADLELEGL AGLATVATED KALQFGRSFQ RHASEPQPGP
   721  RAPTYSVFRT VHTQGQWAYR EGYPLPYEPP ATDGSPGPAP APTPGPGAGR RDSWIERGSR
   781  SLPDSGRASP CPRDGEWFIK MLRAEVEKLE HWCQQMEREA EDYELPEEIL EKIRSAVGST
   841  QLLLSQKVQQ FFRLCQQSMD PTAFPVPTFQ DLAGFWDLLQ LSIEDVTLKF LELQQLKANS
   901  WKLLEPKEEK KVPPPIPKKP LRGRGVPVKE RSLDSVDRQR QEARKRLLAA KRAASFRHSS
   961  ATESADSIEI YIPEAQTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLGAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 44 nTPM
  • cerebral cortex: 42 nTPM
  • basal ganglia: 40 nTPM
  • amygdala: 37 nTPM
  • cerebellum: 23 nTPM
  • hypothalamus: 12 nTPM

Single-cell type

  • brain inhibitory neurons: 69 nCPM
  • brain excitatory neurons: 55 nCPM
  • retinal amacrine cells: 39 nCPM
  • other brain neurons: 32 nCPM
  • cone photoreceptor cells: 31 nCPM
  • retinal ganglion cells: 31 nCPM

Immune cell

  • myeloid DC: 0.8 nTPM
  • classical monocyte: 0.6 nTPM
  • intermediate monocyte: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • thalamus: 225 nTPM
  • cerebral cortex: 220 nTPM
  • amygdala: 219 nTPM
  • basal ganglia: 205 nTPM
  • hippocampal formation: 195 nTPM
  • midbrain: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
2.63
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLGAP3 as an antibody target. Whether an autoantibody or antibody against DLGAP3 could matter depends on whether native DLGAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLGAP3 is annotated at the cell surface, where native DLGAP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLGAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLGAP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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