Seroatlas · Human Serome Atlas

DCST2

DC-STAMP domain-containing protein 2

Also known as: DCST2_HUMAN, FLJ32934

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T1A1
Gene: DCST2
Ensembl: ENSG00000163354
Chromosome: 1
Canonical length: 773 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization and sperm-egg recognition. Predicted to be located in acrosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

773 residues, UniProt reviewed canonical sequence.

>Q5T1A1|DCST2
     1  MPKVMKDVVH PLGGEEPSMA RAVVRSVGGF TLGLSLATAY GLLELLVEGH SPWGCLVGTL
    61  TLAAFLSLGM GFSRQVRATV LLLLPQAFSR QGRTLLLVAA FGLVLQGPCA NTLRNFTRAS
   121  EAVACGAELA LNQTAEVLQR AKQPLVSALN KIKAIARKTK EVADRVRKFF RSIMDGVKHI
   181  ARALRNVWQW LLHIGDVCNS ELGNPYLKCA RVFDDAKDSC MMVIPQAYHL CYVLMPFKLA
   241  LCGLASLVQV FCVIPKYIQP FLRQTIGTPV IQLLNRVRQE FEFNMTATHH FSVDLNASRS
   301  LSQVAMDLHE AVSMKLHRVR EALALMGFTT PLLLVLLYLQ ALFYRYCYLN WDHYDNIYIT
   361  SRFLRMEAVR STAGLPTVLP LSAHEARRYI PPGSIFLSQW EKFFYILETF NLIRHLLLVL
   421  FLVFLDYAVF WVLDLARHQL QGEIVARSPV LVSLTVEGTG YAGNIYRDLV SAFDVLQQGN
   481  ISILSRRCLL RPSEPDSTGY IVIGVMYGLC FFITLFGSYV SRLRRVICAS YYPSREQERI
   541  SYLYNVLLSR RTNLLAALHR SVRRRAADQG HRSAFLVLAS RCPCLGPFVS HFWLHQAYCL
   601  GCGQPQDEGD MENTVSCSTP GCQGLYCLTC FRLLDNTCSV CASPLSYQGD LDLELDSSDE
   661  EGPQLWLAAA QRKDPEQAWL LQQQLQEVLG RSLSMESTSE SSDLDEEKGP QQRKHGQQPL
   721  PEAHQPVSIL TSPEPHRPPE TSSATKGAPT PASEPSVPLS PPSLPDPSHP PPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

retina: 7.9 nTPM
skin: 4.3 nTPM
testis: 3.6 nTPM
cervix: 1.5 nTPM
vagina: 1.5 nTPM
salivary gland: 1.3 nTPM

Single-cell type

early spermatids: 60 nCPM
late primary spermatocytes: 47 nCPM
late spermatids: 42 nCPM
rod photoreceptor cells: 34 nCPM
extravillous trophoblasts: 26 nCPM
cone photoreceptor cells: 23 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.5 nTPM
white matter: 0.5 nTPM
pons: 0.4 nTPM
cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hypothalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

acrosomal membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCST2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DCST1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCST2 as an antibody target. Whether an autoantibody or antibody against DCST2 could matter depends on whether native DCST2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCST2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCST2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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