DCST1

Protein identityUniProt · HPA

UniProt accession

Q5T197

Gene

DCST1

Ensembl

ENSG00000163357

Chromosome

1

Canonical length

706 aa

Protein class

Enzymes, Predicted membrane proteins

Subcellular location

Acrosome,Equatorial segment,Principal piece

OverviewNCBI Gene

This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>Q5T197|DCST1
     1  MDIKHHQNGT RGQRRKQPHT TVQRLLTWGL PVSCSWFLWR QPGEFPVTAL LLGAGAGGLL
    61  AIGLFQLLVN PMNIYEEQKI MFLYSLVGLG AMGWGTSPHI RCASLLLVPK MLGKEGRLFV
   121  LGYALAAIYV GPVANLRHNL NNVIASLGCT VELQINNTRA AWRISTAPLR AMFKDLLSSK
   181  ELLRAETRNI SATFEDLDAQ VNSETGYTPE DTMDSGETAQ GREARQAPAS RLHLSTQKMY
   241  ELKTKLRCSY VVNQAILSCR RWFDRKHEQC MKHIWVPLLT HLLCLPMKFK FFCGIAKVME
   301  VWCRNRIPVE GNFGQTYDSL NQSIRGLDGE FSANIDFKEE KQAGVLGLNT SWERVSTEVR
   361  DYVYRQEARL EWALGLLHVL LSCTFLLVLH ASFSYMDSYN HDIRFDNIYI STYFCQIDDR
   421  RKKLGKRTLL PLRKAEEKTV IFPCKPTIQA SEMSNVVREL LETLPILLLL VVLCGLDWAL
   481  YSIFDTIRHH SFLQYSFRSS HKLEVKVGGD SMLARLLRKT IGALNTSSET VMESNNMPCL
   541  PQPVGLDARA YWRAAVPIGL LVCLCLLQAF GYRLRRVIAA FYFPKREKKR ILFLYNDLLK
   601  KRAAFTKLRR AAILRRERQQ KAPRHPLADI LHRGCPLLRR WLCRRCVVCQ APETPESYVC
   661  RTLDCEAVYC WSCWDDMRQR CPVCTPREEL SSSAFSDSND DTAYAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

6.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.11

gnomAD pLI

0

gnomAD missense Z

0.44

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fusion of sperm to egg plasma membrane involved in single fertilization
• innate immune response
• negative regulation of type I interferon-mediated signaling pathway
• protein ubiquitination
• sperm-egg recognition
• ubiquitin-dependent protein catabolic process

Molecular functions

• ubiquitin protein ligase activity
• zinc ion binding

Cellular components

• acrosomal membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, RING-type
• Dendritic cell-specific transmembrane protein-like
• Cell Surface Receptor and E3 Ligase Protein
• E3 ubiquitin-protein ligase DCST1-like, C-terminal domain
• DC-STAMP-like protein
• E3 ubiquitin-protein ligase DCST1-like, C-terminal RING domain

KeywordsUniProt

• Cell membrane
• Cytoplasmic vesicle
• Glycoprotein
• Immunity
• Innate immunity
• Membrane
• Metal-binding
• Transferase
• Transmembrane
• Transmembrane helix
• Ubl conjugation pathway
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of DCST1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DCST2
• STAT2