Seroatlas · Human Serome Atlas

DCAF8L2

DDB1- and CUL4-associated factor 8-like protein 2

Also known as: DC8L2_HUMAN, WDR42C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7V8
Gene: DCAF8L2
Ensembl: ENSG00000189186
Chromosome: X
Canonical length: 631 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>P0C7V8|DCAF8L2
     1  MSHQEGSTDG LPDLGTESLF SSPEEQSGAV AATEASSDID IATSELSVTV TGDGSDSRDG
    61  GFPNDASTEN RSSDQESASE DIELESLEDF EHFLMSGESL FHYPLVGEEE TEREEEDEEI
   121  QEEGGEEEEE EEEEEEEEEE EEEEEEEQPR AGPQGSGGNH EQYSLEEDQA LEEWVSSETS
   181  ALPRPRWQVV TALHQRQLGS RPRFVYEACG ARAFVQRFRL QYRLADHVGC VNTVHFNQRG
   241  TRLASSGDDL KVIVWDWVRQ RPVLNFESGH TNNVFQAKFL PNCGDSTLAM CARDGQVRVA
   301  ELINASYFNN TKCVAQHRGP AHKLALEPDS PYKFLTSGED AVVFTIDLRQ DRPASKVVVT
   361  RENDKKVGLY TITVNPANTY QFAVGGQDQF VRIYDQRKID KKENNGVLKK FTPHHLVNCD
   421  FPTNITCVVY SHDGTELLAS YNDDDIYLFN SSHSDGAQYS KRFKGHRNNT TVKGVNFYGP
   481  RSEFVVSGSD CGHIFFWEKS SCQIIQFLKG SREGTINCLE PHPYLPVLAC SGLDHDVKIW
   541  TPTAKAATEL TGLKKVIKKN KWERDEDSLH HGSLFDQYML WFLLRHVTQR GRHQDWRSGE
   601  AEFPDEESDE SSSTSETSEE EVQDRVQCMP S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF8L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
ovary: 0.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

sertoli cells: 1,306 nCPM
granulosa cells: 49 nCPM
undifferentiated spermatogonia: 22 nCPM
differentiating spermatogonia: 11 nCPM
early primary spermatocytes: 8 nCPM
ovarian stromal cells: 6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.5 nTPM
cerebral cortex: 0.3 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM
amygdala: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.82
gnomAD missense Z: 1.34
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF8L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DDB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF8L2 as an antibody target. Whether an autoantibody or antibody against DCAF8L2 could matter depends on whether native DCAF8L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF8L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF8L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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