Seroatlas · Human Serome Atlas

DCAF8L1

DDB1- and CUL4-associated factor 8-like protein 1

Also known as: DC8L1_HUMAN, WDR42B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NGE4
Gene: DCAF8L1
Ensembl: ENSG00000226372
Chromosome: X
Canonical length: 600 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 1. However, the CDS of this intronless gene remains intact, it is conserved in other primate species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

600 residues, UniProt reviewed canonical sequence.

>A6NGE4|DCAF8L1
     1  MSHQEGSTGG LPDLVTESLF SSPEEQSGVA AVTAASSDIE MAATEPSTGD GGDTRDGGFL
    61  NDASTENQNT DSESSSEDVE LESMGEGLFG YPLVGEETER EEEEEEMEEE GEEEEQPRMC
   121  PRCGGTNHDQ CLLDEDQALE EWISSETSAL PRSRWQVLTA LRQRQLGSSA RFVYEACGAR
   181  TFVQRFRLQY LLGSHAGSVS TIHFNQRGTR LASSGDDLRV IVWDWVRQKP VLNFESGHDI
   241  NVIQAKFFPN CGDSTLAMCG HDGQVRVAEL INASYCENTK RVAKHRGPAH ELALEPDSPY
   301  KFLTSGEDAV VFTIDLRQDR PASKVVVTRE NDKKVGLYTI SMNPANIYQF AVGGHDQFVR
   361  IYDQRRIDKK ENNGVLKKFT PHHLVYCDFP TNITCVVYSH DGTELLASYN DEDIYLFNSS
   421  LSDGAQYVKR YKGHRNNDTI KCVNFYGPRS EFVVSGSDCG HVFFWEKSSS QIIQFMEGDR
   481  GDIVNCLEPH PYLPVLATSG LDQHVRIWTP TAKTATELTG LKDVIKKNKQ ERDEDNLNYT
   541  DSFDNRMLRF FVRHLLQRAH QPGWRDHGAE FPDEEELDES SSTSDTSEEE GQDRVQCIPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF8L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

testis: 0.9 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 11 nCPM
differentiating spermatogonia: 6 nCPM
undifferentiated spermatogonia: 1 nCPM
early spermatids: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.34
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF8L1 as an antibody target. Whether an autoantibody or antibody against DCAF8L1 could matter depends on whether native DCAF8L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF8L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF8L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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