Seroatlas · Human Serome Atlas

DCAF13

DDB1- and CUL4-associated factor 13

Also known as: DCA13_HUMAN, DKFZP564O0463, Gm83, HSPC064, Sof1, WDSOF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NV06
Gene
DCAF13
Ensembl
ENSG00000164934
Chromosome
8
Canonical length
445 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cell Junctions,Centrosome,Cytosol

OverviewNCBI Gene

Enables nuclear estrogen receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including decidualization; epigenetic programming in the zygotic pronuclei; and spindle assembly involved in female meiosis. Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q9NV06|DCAF13
     1  MKVKMLSRNP DNYVRETKLD LQRVPRNYDP ALHPFEVPRE YIRALNATKL ERVFAKPFLA
    61  SLDGHRDGVN CLAKHPEKLA TVLSGACDGE VRIWNLTQRN CIRTIQAHEG FVRGICTRFC
   121  GTSFFTVGDD KTVKQWKMDG PGYGDEEEPL HTILGKTVYT GIDHHWKEAV FATCGQQVDI
   181  WDEQRTNPIC SMTWGFDSIS SVKFNPIETF LLGSCASDRN IVLYDMRQAT PLKKVILDMR
   241  TNTICWNPME AFIFTAANED YNLYTFDMRA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
   301  SFDKSIRIFP VDKSRSREVY HTKRMQHVIC VKWTSDSKYI MCGSDEMNIR LWKANASEKL
   361  GVLTSREKAA KDYNQKLKEK FQHYPHIKRI ARHRHLPKSI YSQIQEQRIM KEARRRKEVN
   421  RIKHSKPGSV PLVSEKKKHV VAVVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 31 nTPM
  • kidney: 30 nTPM
  • testis: 30 nTPM
  • tonsil: 29 nTPM
  • lymph node: 23 nTPM
  • thymus: 23 nTPM

Single-cell type

  • oocytes: 249 nCPM
  • cardiomyocytes: 153 nCPM
  • late primary spermatocytes: 150 nCPM
  • epicardial cells: 127 nCPM
  • differentiating spermatogonia: 115 nCPM
  • extravillous trophoblasts: 94 nCPM

Immune cell

  • memory B-cell: 61 nTPM
  • T-reg: 58 nTPM
  • myeloid DC: 55 nTPM
  • NK-cell: 53 nTPM
  • naive B-cell: 51 nTPM
  • MAIT T-cell: 49 nTPM

Brain region

  • midbrain: 15 nTPM
  • choroid plexus: 13 nTPM
  • white matter: 11 nTPM
  • pons: 10 nTPM
  • cerebellum: 9.9 nTPM
  • spinal cord: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
-0.69

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 21% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF13 as an antibody target. Whether an autoantibody or antibody against DCAF13 could matter depends on whether native DCAF13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCAF13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...