Seroatlas · Human Serome Atlas

DBP

D site-binding protein

Also known as: DABP, DBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q10586
Gene: DBP
Ensembl: ENSG00000105516
Chromosome: 19
Canonical length: 325 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Transcription factors
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q10586|DBP
     1  MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA
    61  ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD
   121  AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG
   181  HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI
   241  MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
   301  VVAVRQELSH YRAVLSRYQA QHGAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 74 nTPM
basal ganglia: 67 nTPM
skin: 54 nTPM
cerebral cortex: 54 nTPM
skeletal muscle: 54 nTPM
adrenal gland: 51 nTPM

Single-cell type

retinal bipolar cells: 195 nCPM
müller glia: 154 nCPM
retinal horizontal cells: 132 nCPM
retinal pigment epithelial cells: 102 nCPM
retinal amacrine cells: 78 nCPM
enterocytes: 63 nCPM

Immune cell

eosinophil: 4.9 nTPM
myeloid DC: 4.1 nTPM
MAIT T-cell: 3.9 nTPM
T-reg: 3.8 nTPM
plasmacytoid DC: 3.6 nTPM
intermediate monocyte: 3.5 nTPM

Brain region

cerebellum: 68 nTPM
basal ganglia: 66 nTPM
thalamus: 55 nTPM
cerebral cortex: 47 nTPM
midbrain: 46 nTPM
spinal cord: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.23
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DDIT3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DBP as an antibody target. Whether an autoantibody or antibody against DBP could matter depends on whether native DBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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