Seroatlas · Human Serome Atlas

CYSLTR2

Cysteinyl leukotriene receptor 2

Also known as: CLTR2_HUMAN, CysLT(2), CYSLT2R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NS75
Gene
CYSLTR2
Ensembl
ENSG00000152207
Chromosome
13
Canonical length
346 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q9NS75|CYSLTR2
     1  MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF WGVLGNGLSI
    61  YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR GSNWIFGDLA CRIMSYSLYV
   121  NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT SIRSAWILCG IIWILIMASS IMLLDSGSEQ
   181  NGSVTSCLEL NLYKIAKLQT MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV
   241  SHRKALTTII ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF
   301  NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYSLTR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 22 nTPM
  • seminal vesicle: 15 nTPM
  • heart muscle: 7.9 nTPM
  • spleen: 7.1 nTPM
  • lymph node: 3.9 nTPM
  • adrenal gland: 3.7 nTPM

Single-cell type

  • melanocytes: 84 nCPM
  • pericytes: 49 nCPM
  • pituicytes/fscs: 45 nCPM
  • cdc: 42 nCPM
  • granulosa cells: 32 nCPM
  • renal collecting duct principal cells: 30 nCPM

Immune cell

  • eosinophil: 90 nTPM
  • basophil: 7.7 nTPM
  • intermediate monocyte: 6.6 nTPM
  • non-classical monocyte: 4.8 nTPM
  • classical monocyte: 2.2 nTPM
  • myeloid DC: 2.2 nTPM

Brain region

  • cerebral cortex: 7 nTPM
  • hypothalamus: 7 nTPM
  • pons: 6.9 nTPM
  • medulla oblongata: 6.6 nTPM
  • thalamus: 6.4 nTPM
  • midbrain: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYSLTR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYSLTR2 as an antibody target. Whether an autoantibody or antibody against CYSLTR2 could matter depends on whether native CYSLTR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYSLTR2 is annotated at the cell surface, where native CYSLTR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CYSLTR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYSLTR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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