Seroatlas · Human Serome Atlas

CYSLTR1

Cysteinyl leukotriene receptor 1

Also known as: CLTR1_HUMAN, CysLT(1), CysLT1, CYSLT1R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y271
Gene
CYSLTR1
Ensembl
ENSG00000173198
Chromosome
X
Canonical length
337 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q9Y271|CYSLTR1
     1  MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK TYHKKSAFQV
    61  YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST YALYVNLYCS IFFMTAMSFF
   121  RCIAIVFPVQ NINLVTQKKA RFVCVGIWIF VILTSSPFLM AKPQKDEKNN TKCFEPPQDN
   181  QTKNHVLVLH YVSLFVGFII PFVIIIVCYT MIILTLLKKS MKKNLSSHKK AIGMIMVVTA
   241  AFLVSFMPYH IQRTIHLHFL HNETKPCDSV LRMQKSVVIT LSLAASNCCF DPLLYFFSGG
   301  NFRKRLSTFR KHSLSSVTYV PRKKASLPEK GEEICKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYSLTR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 11 nTPM
  • spleen: 10 nTPM
  • lymph node: 8.9 nTPM
  • appendix: 7.1 nTPM
  • esophagus: 6.9 nTPM
  • lung: 6.9 nTPM

Single-cell type

  • innate lymphoid cells: 130 nCPM
  • pdcs: 129 nCPM
  • b-cells: 90 nCPM
  • plasma cells: 90 nCPM
  • microglia: 82 nCPM
  • hofbauer cells: 68 nCPM

Immune cell

  • eosinophil: 86 nTPM
  • neutrophil: 45 nTPM
  • non-classical monocyte: 31 nTPM
  • intermediate monocyte: 27 nTPM
  • basophil: 19 nTPM
  • memory B-cell: 19 nTPM

Brain region

  • spinal cord: 1.8 nTPM
  • medulla oblongata: 1.7 nTPM
  • pons: 1.6 nTPM
  • white matter: 1.6 nTPM
  • choroid plexus: 1.3 nTPM
  • hypothalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0.01
gnomAD missense Z
-0.77
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYSLTR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYSLTR1 as an antibody target. Whether an autoantibody or antibody against CYSLTR1 could matter depends on whether native CYSLTR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYSLTR1 is annotated at the cell surface, where native CYSLTR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CYSLTR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYSLTR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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