Seroatlas · Human Serome Atlas

CYRIB

CYFIP-related Rac1 interactor B

Also known as: BM-009, CYRI, CYRI-B, CYRIB_HUMAN, FAM49B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUQ9
Gene: CYRIB
Ensembl: ENSG00000153310
Chromosome: 8
Canonical length: 324 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables small GTPase binding activity. Involved in several processes, including cellular response to molecule of bacterial origin; negative regulation of small GTPase mediated signal transduction; and regulation of organelle organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q9NUQ9|CYRIB
     1  MGNLLKVLTC TDLEQGPNFF LDFENAQPTE SEKEIYNQVN VVLKDAEGIL EDLQSYRGAG
    61  HEIREAIQHP ADEKLQEKAW GAVVPLVGKL KKFYEFSQRL EAALRGLLGA LTSTPYSPTQ
   121  HLEREQALAK QFAEILHFTL RFDELKMTNP AIQNDFSYYR RTLSRMRINN VPAEGENEVN
   181  NELANRMSLF YAEATPMLKT LSDATTKFVS ENKNLPIENT TDCLSTMASV CRVMLETPEY
   241  RSRFTNEETV SFCLRVMVGV IILYDHVHPV GAFAKTSKID MKGCIKVLKD QPPNSVEGLL
   301  NALRYTTKHL NDETTSKQIK SMLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYRIB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 187 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 187 nTPM
lymph node: 111 nTPM
tonsil: 98 nTPM
appendix: 92 nTPM
spleen: 78 nTPM
thymus: 74 nTPM

Single-cell type

neutrophils: 6,072 nCPM
neutrophil progenitors: 1,953 nCPM
microglia: 1,238 nCPM
monocytes: 744 nCPM
nk-cells: 705 nCPM
cdc: 636 nCPM

Immune cell

neutrophil: 541 nTPM
eosinophil: 388 nTPM
basophil: 331 nTPM
total PBMC: 292 nTPM
myeloid DC: 269 nTPM
intermediate monocyte: 246 nTPM

Brain region

white matter: 114 nTPM
medulla oblongata: 88 nTPM
spinal cord: 84 nTPM
basal ganglia: 83 nTPM
thalamus: 83 nTPM
pons: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYRIB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYRIB as an antibody target. Whether an autoantibody or antibody against CYRIB could matter depends on whether native CYRIB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYRIB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYRIB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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