Seroatlas · Human Serome Atlas

CYRIA

CYFIP-related Rac1 interactor A

Also known as: CYRI-A, CYRIA_HUMAN, DKFZP566A1524, FAM49A, FLJ11080

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0Q0
Gene: CYRIA
Ensembl: ENSG00000197872
Chromosome: 2
Canonical length: 323 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q9H0Q0|CYRIA
     1  MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILA DLQAYKGAGP
    61  EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE KALQSLLESL TCPPYTPTQH
   121  LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN
   181  EMANRMSLFY AEATPMLKTL SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR
   241  SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN
   301  ALRFTTKHLN DESTSKQIRA MLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYRIA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 46 nTPM
thyroid gland: 38 nTPM
basal ganglia: 30 nTPM
amygdala: 26 nTPM
spleen: 26 nTPM
bone marrow: 22 nTPM

Single-cell type

neutrophils: 940 nCPM
monocytes: 818 nCPM
cdc: 631 nCPM
kupffer cells: 438 nCPM
macrophages: 403 nCPM
plasma cells: 359 nCPM

Immune cell

neutrophil: 197 nTPM
non-classical monocyte: 160 nTPM
eosinophil: 141 nTPM
intermediate monocyte: 130 nTPM
classical monocyte: 100 nTPM
myeloid DC: 67 nTPM

Brain region

cerebral cortex: 94 nTPM
basal ganglia: 87 nTPM
hippocampal formation: 70 nTPM
thalamus: 67 nTPM
amygdala: 63 nTPM
midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.21
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYRIA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYRIA as an antibody target. Whether an autoantibody or antibody against CYRIA could matter depends on whether native CYRIA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYRIA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYRIA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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