Seroatlas · Human Serome Atlas

CXCL10

C-X-C motif chemokine 10

Also known as: C7, crg-2, CXL10_HUMAN, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P02778
Gene: CXCL10
Ensembl: ENSG00000169245
Chromosome: 4
Canonical length: 98 aa
Protein class: Cancer-related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>P02778|CXCL10
     1  MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI IPASQFCPRV
    61  EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

appendix: 90 nTPM
lymph node: 64 nTPM
urinary bladder: 42 nTPM
prostate: 37 nTPM
lung: 33 nTPM
thymus: 33 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 177 nCPM
epididymal clear cells: 90 nCPM
fallopian secretory cells: 76 nCPM
epididymal basal cells: 59 nCPM
macrophages: 47 nCPM
cdc: 36 nCPM

Immune cell

intermediate monocyte: 53 nTPM
non-classical monocyte: 37 nTPM
classical monocyte: 22 nTPM
total PBMC: 7.6 nTPM
myeloid DC: 3.5 nTPM
memory B-cell: 1.4 nTPM

Brain region

pons: 22 nTPM
medulla oblongata: 14 nTPM
spinal cord: 5.2 nTPM
thalamus: 4.1 nTPM
basal ganglia: 1.6 nTPM
white matter: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.37
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CXCL10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CXCR3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCL10 as an antibody target. Whether an autoantibody or antibody against CXCL10 could matter depends on whether native CXCL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCL10 is annotated as secreted, so native CXCL10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CXCL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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