Seroatlas · Human Serome Atlas

CTSE

Cathepsin E

Also known as: CATE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P14091
Gene: CTSE
Ensembl: ENSG00000196188
Chromosome: 1
Canonical length: 396 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Vesicles
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>P14091|CTSE
     1  MKTLLLLLLV LLELGEAQGS LHRVPLRRHP SLKKKLRARS QLSEFWKSHN LDMIQFTESC
    61  SMDQSAKEPL INYLDMEYFG TISIGSPPQN FTVIFDTGSS NLWVPSVYCT SPACKTHSRF
   121  QPSQSSTYSQ PGQSFSIQYG TGSLSGIIGA DQVSVEGLTV VGQQFGESVT EPGQTFVDAE
   181  FDGILGLGYP SLAVGGVTPV FDNMMAQNLV DLPMFSVYMS SNPEGGAGSE LIFGGYDHSH
   241  FSGSLNWVPV TKQAYWQIAL DNIQVGGTVM FCSEGCQAIV DTGTSLITGP SDKIKQLQNA
   301  IGAAPVDGEY AVECANLNVM PDVTFTINGV PYTLSPTAYT LLDFVDGMQF CSSGFQGLDI
   361  HPPAGPLWIL GDVFIRQFYS VFDRGNNRVG LAPAVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTSE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 1,103 nTPM

Expression across tissuesHPA

Tissue

stomach: 1,103 nTPM
duodenum: 216 nTPM
small intestine: 52 nTPM
lung: 47 nTPM
bone marrow: 28 nTPM
rectum: 24 nTPM

Single-cell type

foveolar cells: 1,602 nCPM
alveolar cells type 1: 650 nCPM
mucous neck cells: 401 nCPM
transitional alveolar cells: 389 nCPM
parietal cells: 309 nCPM
gastric progenitor cells: 253 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.4 nTPM
naive B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 2.5 nTPM
white matter: 2.5 nTPM
pons: 2.2 nTPM
cerebral cortex: 2.1 nTPM
thalamus: 2.1 nTPM
medulla oblongata: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

endosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTSE as an antibody target. Whether an autoantibody or antibody against CTSE could matter depends on whether native CTSE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTSE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTSE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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