Seroatlas · Human Serome Atlas

CRYGN

Gamma-crystallin N

Also known as: CRGN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXF5
Gene: CRYGN
Ensembl: ENSG00000127377
Chromosome: 7
Canonical length: 182 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q8WXF5|CRYGN
     1  MAQRSGKITL YEGKHFTGQK LEVFGDCDNF QDRGFMNRVN SIHVESGAWV CFNHPDFRGQ
    61  QFILEHGDYP DFFRWNSHSD HMGSCRPVGM HGEHFRLEIF EGCNFTGQCL EFLEDSPFLQ
   121  SRGWVKNCVN TIKVYGDGAA WSPRSFGAED FQLSSSLQSD QGPEEATTKP ATTQPPFLTA
   181  NL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYGN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 15 nTPM
seminal vesicle: 3.1 nTPM
choroid plexus: 1.3 nTPM
parathyroid gland: 1.2 nTPM
pituitary gland: 1.1 nTPM
cervix: 1 nTPM

Single-cell type

decidual stromal cells: 9.2 nCPM
retinal pigment epithelial cells: 8.5 nCPM
pituicytes/fscs: 2.8 nCPM
pituitary stem cells: 2.1 nCPM
pericytes: 1.6 nCPM
müller glia: 1.3 nCPM

Immune cell

memory CD4 T-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM
naive CD8 T-cell: 0.8 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 3.3 nTPM
hippocampal formation: 2.4 nTPM
amygdala: 2.3 nTPM
cerebral cortex: 1.8 nTPM
basal ganglia: 1.6 nTPM
hypothalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of eye lens

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYGN as an antibody target. Whether an autoantibody or antibody against CRYGN could matter depends on whether native CRYGN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYGN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYGN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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