Seroatlas · Human Serome Atlas

CRYGA

Gamma-crystallin A

Also known as: CRGA_HUMAN, CRY-g-A, CRYG1, CRYG5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11844
Gene
CRYGA
Ensembl
ENSG00000168582
Chromosome
2
Canonical length
174 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>P11844|CRYGA
     1  MGKITFYEDR DFQGRCYNCI SDCPNLRVYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR
    61  GKYPDYQHWM GLSDSVQSCR IIPHTSSHKL RLYERDDYRG LMSELTDDCA CVPELFRLPE
   121  IYSLHVLEGC WVLYEMPNYR GRQYLLRPGD YRRYHDWGGA DAKVGSLRRV TDLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYGA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
0.4 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 0.4 nTPM
  • cerebral cortex: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • choroid plexus: 0.1 nTPM

Single-cell type

  • megakaryocyte progenitors: 3.6 nCPM
  • oligodendrocyte progenitor cells: 1.3 nCPM
  • brain inhibitory neurons: 0.7 nCPM
  • brain excitatory neurons: 0.6 nCPM
  • other brain neurons: 0.4 nCPM
  • undifferentiated spermatogonia: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.9 nTPM
  • hypothalamus: 0.7 nTPM
  • amygdala: 0.6 nTPM
  • basal ganglia: 0.6 nTPM
  • hippocampal formation: 0.5 nTPM
  • midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
-0.65
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYGA as an antibody target. Whether an autoantibody or antibody against CRYGA could matter depends on whether native CRYGA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYGA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYGA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRYGA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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