Seroatlas · Human Serome Atlas

CRYBG2

Beta/gamma crystallin domain-containing protein 2

Also known as: AIM1L, CRBG2_HUMAN, FLJ38020

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1P7
Gene: CRYBG2
Ensembl: ENSG00000176092
Chromosome: 1
Canonical length: 1661 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1661 residues, UniProt reviewed canonical sequence.

>Q8N1P7|CRYBG2
     1  MEEAGGPMAR AKARVVSATL TWRQRPPTQE EIKHGFHKVS LVSGAQMEAP QKEMFEFSRR
    61  EEVEVNGFAT QEEETVNCQG PRDTAGSKNF QSHGPIFSKK YIPPPKEKRP EGRLKEAVDQ
   121  SDGSRQAPRT EPPCVGAMAR TELLVPLPGP REPSPHPGVG LTSGSSRSLE EYRVTRTVRT
   181  TTVVGGHVDR RMSSSVTVRP VSSGEALPRG RQVSRMVPPV VVGSPPGSPS RSQAVKVLSN
   241  LVPAGHSPPA SHLPRPTAGG PRSTGLGSTV GAALRQLPET GTAELKDSSA LASTGIPASA
   301  HLPKNQDAPA ACPDRDQGRA PDARACELWQ VLGAPSSTEL PLQTSQGQAS VPSSPRLETH
   361  VPSPGLTHPA KQPVVPTHPG ARLTPLVLPP KKKDGPVDPP AATVLPMVRS EHVTVPGQPP
   421  APSTTRRKDV PSPGGLSAPS SPRNKFVQNS ENVPVLPFTQ REVVKGPGAP AASSPTRKEV
   481  VQGSSASAAS SPTWKEVVKG PGAPAASSPT QKEVVQGSSA PAALFPTWKE VVKGPGAPDA
   541  SFPTWKEVVK GPGAPAASSP TQKEVVQGSG APAALSTTPK EVVKGPGAPA ASSPTQKEVV
   601  KGPCAPAASS PTQKEVVQGS GAPAALSPKS TEVVQGPKGS SSIQKEAVQG IAGSLAPPLT
   661  KEETVQGPIA PATSLPKQDK GVQDSEGSPI SSLTQKEVVQ DPDALPAPSS SVDRVSPSPG
   721  GTPAPVPTGA EASTESQLVS DPTEGKTCTE TSREEDEVAL AADLEIFLDT LRSMEPPEIL
   781  RTHRLPRAPR SSYLSMYATL PAIEEDQLGP WVLGPGPQEV PSLEEKEEEE EEEPENPYLS
   841  DDEKLQRRQE KAGPSPSRDL HPARPTQVSC SPLEMMKKHV AGTKGPHSEL GLELQGGSRP
   901  TSRLGGSLLF GSLVPTAKEA STPEPLGTKL SALLPHGAPG LRKVPGQLPL LCSERSSPTE
   961  KLACSLPLEG WSPALKTQGK LNTRPGKVIF FSESGCQGSG REVWGDIVDA SGWAPVASIR
  1021  VVRGCWVLYE EPEFRGQKLV LPEGDMELRT PGTKWSPQGI GSLRRVVWDY STPEISLFSE
  1081  EGLKGEQVKL TEALKNSQGL EKPLQVASAT VSAGLWLLYP KPLFEDTPYI LEPGEYPTSE
  1141  AWGTSDPSVG SLKPMRLGCP SVEKPGEPRA VVYEAPGFQG RSWEVSRDIY NLQQPEDSQS
  1201  PHLASVGSLR VLGGCWVGYE KEGFRGHQYL LEEGEYPDWS HWGGYDELLT SLRVIRTDFG
  1261  DPAVVLFEAM DFEGHGVEVS KALPDVELVQ HGPSTQAIHV LSGVWVAYQE VGFSGEQYVL
  1321  EKGVYRNCED WGAGNSTLAS LQPVLQVGEH DLHFVSKIQL FSRPDFLGDH FSFEDDQAAL
  1381  PASFRPQSCR VHGGSWILFD ETNFEGDQHI LSEGEFPTLT AMGCLASTVL GSLQKVSLHF
  1441  SEPSIFLYGL ECFEGKEIEL SREVRSLQAE GFNNHVLSVR IKGGIWVLCE HSDFRGRQWL
  1501  VGSCEITNWL TYSGTQRVGS LYPIKQRRVY FRLWNAALGG FLAVPDHVED MKAGRVVVAD
  1561  PQAGGSCIWY YEDGLLKNQM APTMSLQVIG PPSPGSKVVL WAESRLPRQT WSISESGHIC
  1621  SQMFEGQILD VKGGRGYDRD HVVLWEPDED RASQIWTIHV L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYBG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

esophagus: 62 nTPM
vagina: 24 nTPM
skin: 23 nTPM
cervix: 19 nTPM
urinary bladder: 7.8 nTPM
salivary gland: 6.5 nTPM

Single-cell type

esophageal apical cells: 456 nCPM
esophageal suprabasal cells: 172 nCPM
syncytiotrophoblasts: 120 nCPM
ocular epithelial cells: 114 nCPM
urothelial cells: 109 nCPM
suprabasal keratinocytes: 97 nCPM

Immune cell

neutrophil: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbohydrate binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYBG2 as an antibody target. Whether an autoantibody or antibody against CRYBG2 could matter depends on whether native CRYBG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYBG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYBG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...