Seroatlas · Human Serome Atlas

CRYBG1

Beta/gamma crystallin domain-containing protein 1

Also known as: CRBG1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4K1
Gene: CRYBG1
Canonical length: 2131 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CRYBG1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2131 residues, UniProt reviewed canonical sequence.

>Q9Y4K1|CRYBG1
     1  MPLSPPAQGD PGEPSPCRPP KKHTTFHLWR SKKKQQPAPP DCGVFVPHPL PAPAGEARAL
    61  DVVDGKYVVR DSQEFPLHCG ESQFFHTTSE ALGSLLLESG IFKKSRAQPP EDNRRKPVLG
   121  KLGTLFTAGR RRNSRNGLES PTRSNAKPLS PKDVVASPKL PERESERSRS QSSQLKQTDT
   181  SEEGSPRENP REAEGELPES GGPAAPPDAE LSPRWSSSAA AVAVQQCHEN DSPQLEPLEA
   241  EGEPFPDATT TAKQLHSSPG NSSRQENAET PARSPGEDAS PGAGHEQEAF LGVRGAPGSP
   301  TQERPAGGLG EAPNGAPSVC AEEGSLGPRN ARSQPPKGAS DLPGEPPAEG AAHTASSAQA
   361  DCTARPKGHA HPAKVLTLDI YLSKTEGAQV DEPVVITPRA EDCGDWDDME KRSSGRRSGR
   421  RRGSQKSTDS PGADAELPES AARDDAVFDD EVAPNAASDN ASAEKKVKSP RAALDGGVAS
   481  AASPESKPSP GTKGQLRGES DRSKQPPPAS SPTKRKGRSR ALEAVPAPPA SGPRAPAKES
   541  PPKRVPDPSP VTKGTAAESG EEAARAIPRE LPVKSSSLLP EIKPEHKRGP LPNHFNGRAE
   601  GGRSRELGRA AGAPGASDAD GLKPRNHFGV GRSTVTTKVT LPAKPKHVEL NLKTPKNLDS
   661  LGNEHNPFSQ PVHKGNTATK ISLFENKRTN SSPRHTDIRG QRNTPASSKT FVGRAKLNLA
   721  KKAKEMEQPE KKVMPNSPQN GVLVKETAIE TKVTVSEEEI LPATRGMNGD SSENQALGPQ
   781  PNQDDKADVQ TDAGCLSEPV ASALIPVKDH KLLEKEDSEA ADSKSLVLEN VTDTAQDIPT
   841  TVDTKDLPPT AMPKPQHTFS DSQSPAESSP GPSLSLSAPA PGDVPKDTCV QSPISSFPCT
   901  DLKVSENHKG CVLPVSRQNN EKMPLLELGG ETTPPLSTER SPEAVGSECP SRVLVQVRSF
   961  VLPVESTQDV SSQVIPESSE VREVQLPTCH SNEPEVVSVA SCAPPQEEVL GNEHSHCTAE
  1021  LAAKSGPQVI PPASEKTLPI QAQSQGSRTP LMAESSPTNS PSSGNHLATP QRPDQTVTNG
  1081  QDSPASLLNI SAGSDDSVFD SSSDMEKFTE IIKQMDSAVC MPMKRKKARM PNSPAPHFAM
  1141  PPIHEDHLEK VFDPKVFTFG LGKKKESQPE MSPALHLMQN LDTKSKLRPK RASAEQSVLF
  1201  KSLHTNTNGN SEPLVMPEIN DKENRDVTNG GIKRSRLEKS ALFSSLLSSL PQDKIFSPSV
  1261  TSVNTMTTAF STSQNGSLSQ SSVSQPTTEG APPCGLNKEQ SNLLPDNSLK VFNFNSSSTS
  1321  HSSLKSPSHM EKYPQKEKTK EDLDSRSNLH LPETKFSELS KLKNDDMEKA NHIESVIKSN
  1381  LPNCANSDTD FMGLFKSSRY DPSISFSGMS LSDTMTLRGS VQNKLNPRPG KVVIYSEPDV
  1441  SEKCIEVFSD IQDCSSWSLS PVILIKVVRG CWILYEQPNF EGHSIPLEEG ELELSGLWGI
  1501  EDILERHEEA ESDKPVVIGS IRHVVQDYRV SHIDLFTEPE GLGILSSYFD DTEEMQGFGV
  1561  MQKTCSMKVH WGTWLIYEEP GFQGVPFILE PGEYPDLSFW DTEEAYIGSM RPLKMGGRKV
  1621  EFPTDPKVVV YEKPFFEGKC VELETGMCSF VMEGGETEEA TGDDHLPFTS VGSMKVLRGI
  1681  WVAYEKPGFT GHQYLLEEGE YRDWKAWGGY NGELQSLRPI LGDFSNAHMI MYSEKNFGSK
  1741  GSSIDVLGIV ANLKETGYGV KTQSINVLSG VWVAYENPDF TGEQYILDKG FYTSFEDWGG
  1801  KNCKISSVQP ICLDSFTGPR RRNQIHLFSE PQFQGHSQSF EETTSQIDDS FSTKSCRVSG
  1861  GSWVVYDGEN FTGNQYVLEE GHYPCLSAMG CPPGATFKSL RFIDVEFSEP TIILFEREDF
  1921  KGKKIELNAE TVNLRSLGFN TQIRSVQVIG GIWVTYEYGS YRGRQFLLSP AEVPNWYEFS
  1981  GCRQIGSLRP FVQKRIYFRL RNKATGLFMS TNGNLEDLKL LRIQVMEDVG ADDQIWIYQE
  2041  GCIKCRIAED CCLTIVGSLV TSGSKLGLAL DQNADSQFWS LKSDGRIYSK LKPNLVLDIK
  2101  GGTQYDQNHI ILNTVSKEKF TQVWEAMVLY T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYBG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

placenta: 68 nTPM
esophagus: 66 nTPM
skin: 40 nTPM
tonsil: 32 nTPM
duodenum: 24 nTPM
prostate: 24 nTPM

Single-cell type

esophageal apical cells: 2,190 nCPM
syncytiotrophoblasts: 1,008 nCPM
choroid plexus epithelial cells: 806 nCPM
urothelial cells: 722 nCPM
ocular epithelial cells: 642 nCPM
esophageal suprabasal cells: 575 nCPM

Immune cell

MAIT T-cell: 10 nTPM
T-reg: 9.9 nTPM
memory CD4 T-cell: 9.8 nTPM
myeloid DC: 8.6 nTPM
memory CD8 T-cell: 8.5 nTPM
gdT-cell: 7.4 nTPM

Brain region

choroid plexus: 85 nTPM
hippocampal formation: 5 nTPM
thalamus: 4.7 nTPM
medulla oblongata: 2.9 nTPM
midbrain: 2.6 nTPM
pons: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbohydrate binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYBG1 as an antibody target. Whether an autoantibody or antibody against CRYBG1 could matter depends on whether native CRYBG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYBG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYBG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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