Seroatlas · Human Serome Atlas

CPZ

Carboxypeptidase Z

Also known as: CBPZ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q66K79
Gene: CPZ
Ensembl: ENSG00000109625
Chromosome: 4
Canonical length: 652 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Plasma membrane
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q66K79|CPZ
     1  MPPPLPLLLL TVLVVAAARP GCEFERNPAG ECHRPPAADS ATCVDLQLRT CSDAAYNHTT
    61  FPNLLQHRSW EVVEASSEYI LLSVLHQLLE GQCNPDLRLL GCAVLAPRCE GGWVRRPCRH
   121  ICEGLREVCQ PAFDAIDMAW PYFLDCHRYF TREDEGCYDP LEKLRGGLEA DEALPSGLPP
   181  TFIRFSHHSY AQMVRVLRRT ASRCAHVART YSIGRSFDGR ELLVIEFSSR PGQHELMEPE
   241  VKLIGNIHGN EVAGREMLIY LAQYLCSEYL LGNPRIQRLL NTTRIHLLPS MNPDGYEVAA
   301  AEGAGYNGWT SGRQNAQNLD LNRNFPDLTS EYYRLAETRG ARSDHIPIPQ HYWWGKVAPE
   361  TKAIMKWMQT IPFVLSASLH GGDLVVSYPF DFSKHPQEEK MFSPTPDEKM FKLLSRAYAD
   421  VHPMMMDRSE NRCGGNFLKR GSIINGADWY SFTGGMSDFN YLHTNCFEIT VELGCVKFPP
   481  EEALYILWQH NKESLLNFVE TVHRGIKGVV TDKFGKPVKN ARISVKGIRH DITTAPDGDY
   541  WRLLPPGIHI VIAQAPGYAK VIKKVIIPAR MKRAGRVDFI LQPLGMGPKN FIHGLRRTGP
   601  HDPLGGASSL GEATEPDPLR ARRQPSADGS KPWWWSYFTS LSTHRPRWLL KY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 145 nTPM

Expression across tissuesHPA

Tissue

ovary: 145 nTPM
placenta: 40 nTPM
cervix: 34 nTPM
gallbladder: 29 nTPM
vagina: 25 nTPM
seminal vesicle: 23 nTPM

Single-cell type

ovarian stromal cells: 1.9 nCPM
granulosa cells: 1.6 nCPM
fibroblasts: 1.2 nCPM
bergmann glia: 1 nCPM
brain excitatory neurons: 0.9 nCPM
astrocytes: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 6 nTPM
choroid plexus: 4.9 nTPM
spinal cord: 2.5 nTPM
basal ganglia: 2 nTPM
pons: 1.7 nTPM
white matter: 1.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CPZ.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 310 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Disease | ImmuneIEDB

Conditions an epitope on CPZ was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -4.43
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase M14, carboxypeptidase A
Carboxypeptidase-like, regulatory domain superfamily
Frizzled domain
Frizzled cysteine-rich domain superfamily
Peptidase M14 domain-containing protein
Zinc carboxypeptidases, zinc-binding region 2
Zinc carboxypeptidase
Fz domain
Carboxypeptidase regulatory-like domain
Metallocarboxypeptidase Z, carboxypeptidase domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPZ as an antibody target. Whether an autoantibody or antibody against CPZ could matter depends on whether native CPZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPZ is annotated as secreted, so native CPZ circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CPZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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