Seroatlas · Human Serome Atlas

CPED1

Cadherin-like and PC-esterase domain-containing protein 1

Also known as: C7orf58, CPED1_HUMAN, FLJ21986

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D0V7
Gene: CPED1
Ensembl: ENSG00000106034
Chromosome: 7
Canonical length: 1026 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1026 residues, UniProt reviewed canonical sequence.

>A4D0V7|CPED1
     1  MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP HTSTETQASR
    61  CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI LYRPPFYSKT ELQLHQHILT
   121  QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW DLLICLSSKK AEGTPCISKE VMCQLGLHQK
   181  ANRLPEIQQP LCRKEGLCQI VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW
   241  KPGDWSREQL NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK
   301  KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK TFHRCRFCFQ
   361  LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE FLLNDTFNFL FPNESSLSIF
   421  SEIFQRLYRS DVFKGENYQK ELNQCLSLEE INSIMTFIKE LGSLGQFQLL FPSTTPGIQS
   481  LMHEFYDVAN PVGNPGSVLT QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV
   541  PFDAIENKKA AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV
   601  PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES PAHGETLITY
   661  KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ PISSDYIEAI LQSELKRCPS
   721  GDMKGQWIVP CLSCSDNRTC DWREITWQPH NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR
   781  GIMYYLIERL NETLQEWQKV HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH
   841  LLQRSRPLEN TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD
   901  GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC GCHFHEVVKS
   961  KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP YHVRGPINQV CSEILLSRMC
  1021  ANKRTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

ovary: 59 nTPM
blood vessel: 53 nTPM
adipose tissue: 52 nTPM
liver: 41 nTPM
smooth muscle: 36 nTPM
tongue: 36 nTPM

Single-cell type

myonuclei: 2,841 nCPM
microglia: 753 nCPM
adipocytes: 386 nCPM
cardiomyocytes: 375 nCPM
fibro-adipogenic progenitors: 284 nCPM
vascular smooth muscle cells: 267 nCPM

Immune cell

myeloid DC: 25 nTPM
plasmacytoid DC: 15 nTPM
intermediate monocyte: 11 nTPM
classical monocyte: 11 nTPM
non-classical monocyte: 7.6 nTPM
total PBMC: 2.9 nTPM

Brain region

choroid plexus: 17 nTPM
white matter: 16 nTPM
medulla oblongata: 15 nTPM
thalamus: 14 nTPM
pons: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

NXPE, C-terminal
NXPE family member 4-like, C-terminal domain
Cadherin-like beta-sandwich-like domain
Cadherin-like beta sandwich domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPED1 as an antibody target. Whether an autoantibody or antibody against CPED1 could matter depends on whether native CPED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPED1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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