COX8A

Protein identityUniProt · HPA

UniProt accession

P10176

Gene

COX8A

Ensembl

ENSG00000176340

Chromosome

11

Canonical length

69 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

69 residues, UniProt reviewed canonical sequence.

>P10176|COX8A
     1  MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEGKLGIMEL AVGLTSCFVT FLLPAGWILS
    61  HLETYRRPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

1,430 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COX8A.

Disease | AllUniProt

Conditions COX8A is implicated in, by any mechanism.

• Mitochondrial complex IV deficiency, nuclear type 15 (MC4DN15) MIM:619059

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 35 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Mitochondrial complex IV deficiency, nuclear type 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.84

gnomAD pLI

0.12

gnomAD missense Z

0.15

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular respiration
• generation of precursor metabolites and energy
• mitochondrial electron transport, cytochrome c to oxygen

Molecular functions

• cytochrome-c oxidase activity

Cellular components

• mitochondrial inner membrane
• mitochondrial membrane
• mitochondrion
• respiratory chain complex IV

Protein domainsUniProt · Pfam · InterPro

• Cytochrome c oxidase, subunit 8
• Cytochrome c oxidase, subunit 8 superfamily
• Cytochrome oxidase c subunit VIII

KeywordsUniProt

• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Primary mitochondrial disease
• Transit peptide
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of COX8A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NPM1