COX7A2

Protein identityUniProt · HPA

UniProt accession

P14406

Gene

COX7A2

Ensembl

ENSG00000112695

Chromosome

6

Canonical length

83 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

83 residues, UniProt reviewed canonical sequence.

>P14406|COX7A2
     1  MLRNLLALRQ IGQRTISTAS RRHFKNKVPE KQKLFQEDDE IPLYLKGGVA DALLYRATMI
    61  LTVGGTAYAI YELAVASFPK KQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX7A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

769 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.54

gnomAD pLI

0

gnomAD missense Z

-0.42

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular respiration
• mitochondrial electron transport, cytochrome c to oxygen
• oxidative phosphorylation
• proton transmembrane transport

Molecular functions

• oxidoreductase activity

Cellular components

• mitochondrial inner membrane
• mitochondrial membrane
• mitochondrion
• respiratory chain complex
• respiratory chain complex IV

Protein domainsUniProt · Pfam · InterPro

• Cytochrome c oxidase subunit VIIa, metazoa
• Cytochrome c oxidase, subunit VIIa superfamily
• Cytochrome c oxidase subunit VII
• Cytochrome c oxidase subunit VII

KeywordsUniProt

• Acetylation
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Oxidoreductase
• Transit peptide
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of COX7A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PET100
• MT-CO2