Seroatlas · Human Serome Atlas

COX6C

Cytochrome c oxidase subunit 6C

Also known as: COX6C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09669
Gene
COX6C
Ensembl
ENSG00000164919
Chromosome
8
Canonical length
75 aa
Protein class
Metabolic proteins, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

75 residues, UniProt reviewed canonical sequence.

>P09669|COX6C
     1  MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA DFYRNYDVMK
    61  DFEEMRKAGI FQSVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX6C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
727 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 727 nTPM
  • skeletal muscle: 626 nTPM
  • tongue: 516 nTPM
  • amygdala: 420 nTPM
  • cerebral cortex: 400 nTPM
  • midbrain: 362 nTPM

Single-cell type

  • parietal cells: 5,086 nCPM
  • syncytiotrophoblasts: 2,329 nCPM
  • hepatocytes: 2,107 nCPM
  • decidual stromal cells: 2,066 nCPM
  • enterocytes: 1,924 nCPM
  • colonocytes: 1,633 nCPM

Immune cell

  • basophil: 349 nTPM
  • naive CD4 T-cell: 321 nTPM
  • plasmacytoid DC: 303 nTPM
  • naive CD8 T-cell: 296 nTPM
  • T-reg: 274 nTPM
  • memory CD4 T-cell: 272 nTPM

Brain region

  • cerebral cortex: 140 nTPM
  • hypothalamus: 111 nTPM
  • thalamus: 108 nTPM
  • hippocampal formation: 103 nTPM
  • choroid plexus: 102 nTPM
  • midbrain: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0.05
gnomAD missense Z
0.08
DepMap mean gene effect
-0.4
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mitochondrial cytochrome c oxidase subunit VIc/VIIs
  • Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily
  • Cytochrome c oxidase subunit VIc
  • Cytochrome c oxidase subunit VIc

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COX6C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COX6C as an antibody target. Whether an autoantibody or antibody against COX6C could matter depends on whether native COX6C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COX6C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COX6C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COX6C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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