COX19
Cytochrome c oxidase assembly protein COX19
Also known as: COX19_HUMAN, MGC104475
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q49B96
- Gene
- COX19
- Ensembl
- ENSG00000240230
- Chromosome
- 7
- Canonical length
- 90 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
90 residues, UniProt reviewed canonical sequence.
>Q49B96|COX19
1 MSTAMNFGTK SFQPRPPDKG SFPLDHLGEC KSFKEKFMKC LHNNNFENAL CRKESKEYLE
61 CRMERKLMLQ EPLEKLGFGD LTSGKSEAKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against COX19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 9.5 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 9.5 nTPM
- skeletal muscle: 7.1 nTPM
- cerebellum: 6.7 nTPM
- skin: 6.4 nTPM
- bone marrow: 6.3 nTPM
- spleen: 6.3 nTPM
Single-cell type
- gastric progenitor cells: 87 nCPM
- hepatic stellate cells: 78 nCPM
- esophageal apical cells: 67 nCPM
- endometrial ciliated cells: 66 nCPM
- syncytiotrophoblasts: 65 nCPM
- pdcs: 64 nCPM
Immune cell
- basophil: 9.4 nTPM
- eosinophil: 8.3 nTPM
- plasmacytoid DC: 7.9 nTPM
- naive CD4 T-cell: 7.5 nTPM
- naive CD8 T-cell: 7.2 nTPM
- memory B-cell: 6.6 nTPM
Brain region
- white matter: 16 nTPM
- cerebellum: 15 nTPM
- pons: 13 nTPM
- medulla oblongata: 12 nTPM
- cerebral cortex: 12 nTPM
- basal ganglia: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.02
- DepMap mean gene effect
- -0.24
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cysteine alpha-hairpin motif superfamily
- CHCH
- CHCH domain
- Cytochrome c oxidase assembly protein COX19
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of COX19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads COX19 as an antibody target. Whether an autoantibody or antibody against COX19 could matter depends on whether native COX19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
COX19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label COX19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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