Seroatlas · Human Serome Atlas

COX11

Cytochrome c oxidase assembly protein COX11, mitochondrial

Also known as: COX11_HUMAN, COX11P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6N1
Gene
COX11
Ensembl
ENSG00000166260
Chromosome
17
Canonical length
276 aa
Protein class
Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q9Y6N1|COX11
     1  MGGLWRPGWR CVPFCGWRWI HPGSPTRAAE RVEPFLRPEW SGTGGAERGL RWLGTWKRCS
    61  LRARHPALQP PRRPKSSNPF TRAQEEERRR QNKTTLTYVA AVAVGMLGAS YAAVPLYRLY
   121  CQTTGLGGSA VAGHASDKIE NMVPVKDRII KISFNADVHA SLQWNFRPQQ TEIYVVPGET
   181  ALAFYRAKNP TDKPVIGIST YNIVPFEAGQ YFNKIQCFCF EEQRLNPQEE VDMPVFFYID
   241  PEFAEDPRMI KVDLITLSYT FFEAKEGHKL PVPGYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 29 nTPM
  • skeletal muscle: 20 nTPM
  • retina: 19 nTPM
  • liver: 18 nTPM
  • small intestine: 17 nTPM
  • kidney: 16 nTPM

Single-cell type

  • late primary spermatocytes: 123 nCPM
  • cone photoreceptor cells: 89 nCPM
  • enteric stem cells: 76 nCPM
  • rod photoreceptor cells: 71 nCPM
  • enteric transient amplifying cells: 70 nCPM
  • parietal cells: 67 nCPM

Immune cell

  • naive B-cell: 8 nTPM
  • T-reg: 7.9 nTPM
  • naive CD8 T-cell: 7 nTPM
  • myeloid DC: 6.7 nTPM
  • memory CD4 T-cell: 6.6 nTPM
  • MAIT T-cell: 5.7 nTPM

Brain region

  • cerebral cortex: 27 nTPM
  • cerebellum: 27 nTPM
  • choroid plexus: 27 nTPM
  • white matter: 25 nTPM
  • basal ganglia: 24 nTPM
  • thalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COX11.

Disease | AllUniProt

Conditions COX11 is implicated in, by any mechanism.

  • Mitochondrial complex IV deficiency, nuclear type 23 (MC4DN23) MIM:620275

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Mitochondrial complex IV deficiency, nuclear type 23

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.02
gnomAD missense Z
0.67
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cytochrome c oxidase assembly protein CtaG/Cox11
  • Cytochrome c oxidase assembly protein CtaG/Cox11, domain superfamily
  • Cytochrome c oxidase assembly protein CtaG/Cox11

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COX11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COX11 as an antibody target. Whether an autoantibody or antibody against COX11 could matter depends on whether native COX11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COX11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COX11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COX11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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