CNIH4
Protein cornichon homolog 4
Also known as: CNIH4_HUMAN, HSPC163
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P003
- Gene
- CNIH4
- Ensembl
- ENSG00000143771
- Chromosome
- 1
- Canonical length
- 139 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Enables CCR5 chemokine receptor binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
139 residues, UniProt reviewed canonical sequence.
>Q9P003|CNIH4
1 MEAVVFVFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP ELIGHTIVTV
61 LLLMSLHWFI FLLNLPVATW NIYRYIMVPS GNMGVFDPTE IHNRGQLKSH MKEAMIKLGF
121 HLLCFFMYLY SMILALINDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CNIH4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 28 nTPM
- bone marrow: 25 nTPM
- blood vessel: 24 nTPM
- skeletal muscle: 24 nTPM
- esophagus: 22 nTPM
- adipose tissue: 21 nTPM
Single-cell type
- gastric progenitor cells: 449 nCPM
- esophageal apical cells: 311 nCPM
- esophageal suprabasal cells: 279 nCPM
- extravillous trophoblasts: 231 nCPM
- esophageal basal cells: 222 nCPM
- syncytiotrophoblasts: 195 nCPM
Immune cell
- non-classical monocyte: 155 nTPM
- intermediate monocyte: 107 nTPM
- eosinophil: 73 nTPM
- classical monocyte: 60 nTPM
- total PBMC: 58 nTPM
- basophil: 55 nTPM
Brain region
- choroid plexus: 21 nTPM
- hypothalamus: 18 nTPM
- pons: 17 nTPM
- medulla oblongata: 17 nTPM
- midbrain: 16 nTPM
- basal ganglia: 16 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.23
- DepMap mean gene effect
- -0.29
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CNIH4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CNIH4 as an antibody target. Whether an autoantibody or antibody against CNIH4 could matter depends on whether native CNIH4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CNIH4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CNIH4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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