Seroatlas · Human Serome Atlas

CLDND2

Claudin domain-containing protein 2

Also known as: CLDN2_HUMAN, MGC33839

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHS1
Gene
CLDND2
Ensembl
ENSG00000160318
Chromosome
19
Canonical length
167 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q8NHS1|CLDND2
     1  MGVKRSLQSG GILLSLVANV LMVLSTATNY WTRQQEGHSG LWQECNHGIC SSIPCQTTLA
    61  VTVACMVLAV GVGVVGMVMG LRIRCDEGES LRGQTTSAFL FLGGLLLLTA LIGYTVKNAW
   121  KNNVFFSWSY FSGWLALPFS ILAGFCFLLA DMIMQSTDAI SGFPVCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDND2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • testis: 43 nTPM
  • bone marrow: 9.1 nTPM
  • choroid plexus: 7.1 nTPM
  • midbrain: 6.7 nTPM
  • cerebral cortex: 6.4 nTPM
  • spleen: 6.3 nTPM

Single-cell type

  • late primary spermatocytes: 283 nCPM
  • early spermatids: 264 nCPM
  • late spermatids: 14 nCPM
  • goblet cells: 6.6 nCPM
  • enteric stem cells: 6.5 nCPM
  • gastric chief cells: 5.5 nCPM

Immune cell

  • basophil: 3 nTPM
  • NK-cell: 2.9 nTPM
  • memory CD8 T-cell: 2.2 nTPM
  • eosinophil: 2.1 nTPM
  • gdT-cell: 1.7 nTPM
  • plasmacytoid DC: 1.6 nTPM

Brain region

  • cerebral cortex: 9.6 nTPM
  • hypothalamus: 7.3 nTPM
  • cerebellum: 7.1 nTPM
  • hippocampal formation: 7 nTPM
  • pons: 6.9 nTPM
  • medulla oblongata: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0
gnomAD missense Z
0.41
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDND2 as an antibody target. Whether an autoantibody or antibody against CLDND2 could matter depends on whether native CLDND2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDND2 is annotated at the cell surface, where native CLDND2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDND2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLDND2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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