Seroatlas · Human Serome Atlas

CLDN7

Claudin-7

Also known as: CEPTRL2, CLD7_HUMAN, CPETRL2, Hs.84359

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95471
Gene
CLDN7
Ensembl
ENSG00000181885
Chromosome
17
Canonical length
211 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>O95471|CLDN7
     1  MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG
    61  MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM
   121  GGGIIFIVAG LAALVACSWY GHQIVTDFYN PLIPTNIKYE FGPAIFIGWA GSALVILGGA
   181  LLSCSCPGNE SKAGYRVPRS YPKSNSSKEY V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
325 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 325 nTPM
  • colon: 322 nTPM
  • small intestine: 239 nTPM
  • salivary gland: 162 nTPM
  • duodenum: 138 nTPM
  • rectum: 121 nTPM

Single-cell type

  • alveolar cells type 1: 73 nCPM
  • esophageal apical cells: 62 nCPM
  • endometrial secretory cells: 54 nCPM
  • enterocytes: 53 nCPM
  • respiratory deuterosomal cells: 42 nCPM
  • breast secretory cells: 37 nCPM

Immune cell

  • naive CD8 T-cell: 1.7 nTPM
  • MAIT T-cell: 1.3 nTPM
  • naive B-cell: 0.9 nTPM
  • naive CD4 T-cell: 0.9 nTPM
  • intermediate monocyte: 0.8 nTPM
  • memory CD8 T-cell: 0.8 nTPM

Brain region

  • white matter: 1.9 nTPM
  • thalamus: 1.5 nTPM
  • medulla oblongata: 1.3 nTPM
  • pons: 1.2 nTPM
  • cerebellum: 1.1 nTPM
  • cerebral cortex: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLDN7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN7 as an antibody target. Whether an autoantibody or antibody against CLDN7 could matter depends on whether native CLDN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN7 is annotated at the cell surface, where native CLDN7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLDN7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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