Seroatlas · Human Serome Atlas

CLDN24

Claudin-24

Also known as: CLD24_HUMAN, CLDN21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NM45
Gene: CLDN24
Ensembl: ENSG00000185758
Chromosome: 4
Canonical length: 220 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in the genome.[provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>A6NM45|CLDN24
     1  MALIFRTAMQ SVGLLLSLLG WILSIITTYL PHWKNLNLDL NEMENWTMGL WQTCVIQEEV
    61  GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF GLDCLRIGES QRDLKRRLLI
   121  LGGILSWASG ITALVPVSWV AHKTVQEFWD ENVPDFVPRW EFGEALFLGW FAGLSLLLGG
   181  CLLNCAACSS HAPLALGHYA VAQMQTQCPY LEDGTADPQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

kidney: 0.7 nTPM
salivary gland: 0.3 nTPM
retina: 0.2 nTPM
appendix: 0.1 nTPM
esophagus: 0.1 nTPM
lung: 0.1 nTPM

Single-cell type

cardiomyocytes: 0.5 nCPM
endometrial luminal cells: 0.1 nCPM
mast cells: 0.1 nCPM
proximal tubule cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.3 nTPM
amygdala: 2 nTPM
cerebral cortex: 1.9 nTPM
medulla oblongata: 1.8 nTPM
basal ganglia: 1.7 nTPM
midbrain: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.45

OntologyGO

Biological processes

Molecular functions

structural molecule activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN24 as an antibody target. Whether an autoantibody or antibody against CLDN24 could matter depends on whether native CLDN24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN24 is annotated at the cell surface, where native CLDN24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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