Seroatlas · Human Serome Atlas

CLDN22

Claudin-22

Also known as: CLD22_HUMAN, CLDN21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7P3
Gene: CLDN22
Ensembl: ENSG00000177300
Chromosome: 4
Canonical length: 220 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q8N7P3|CLDN22
     1  MALVFRTVAQ LAGVSLSLLG WVLSCLTNYL PHWKNLNLDL NEMENWTMGL WQTCVIQEEV
    61  GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF GLDCLRIGES QRDLKRRLLI
   121  LGGILSWASG VTALVPVSWV AHKTVQEFWD ENVPDFVPRW EFGEALFLGW FAGLSLLLGG
   181  CLLHCAACSS HAPLASGHYA VAQTQDHHQE LETRNTNLKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 6.9 nTPM
fallopian tube: 1.1 nTPM
esophagus: 0.6 nTPM
retina: 0.2 nTPM
endometrium: 0.1 nTPM
kidney: 0.1 nTPM

Single-cell type

endometrial luminal cells: 135 nCPM
epicardial cells: 23 nCPM
respiratory deuterosomal cells: 19 nCPM
respiratory secretory cells: 16 nCPM
submucosal glandular cells: 12 nCPM
cardiomyocytes: 8.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.04
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN22 as an antibody target. Whether an autoantibody or antibody against CLDN22 could matter depends on whether native CLDN22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN22 is annotated at the cell surface, where native CLDN22 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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