Seroatlas · Human Serome Atlas

CLDN20

Claudin-20

Also known as: CLD20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56880
Gene: CLDN20
Ensembl: ENSG00000171217
Chromosome: 6
Canonical length: 219 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>P56880|CLDN20
     1  MASAGLQLLA FILALSGVSG VLTATLLPNW KVNVDVDSNI ITAIVQLHGL WMDCTWYSTG
    61  MFSCALKHSI LSLPIHVQAA RATMVLACVL SALGICTSTV GMKCTRLGGD RETKSHASFA
   121  GGVCFMSAGI SSLISTVWYT KEIIANFLDL TVPESNKHEP GGAIYIGFIS AMLLFISGMI
   181  FCTSCIKRNP EARLDPPTQQ PISNTQLENN STHNLKDYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

retina: 1 nTPM
bone marrow: 0.8 nTPM
skin: 0.8 nTPM
spinal cord: 0.6 nTPM
smooth muscle: 0.5 nTPM
cerebral cortex: 0.3 nTPM

Single-cell type

cardiomyocytes: 87 nCPM
epicardial cells: 25 nCPM
myonuclei: 25 nCPM
adipocytes: 21 nCPM
retinal horizontal cells: 14 nCPM
mast cells: 14 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 7 nTPM
cerebellum: 6.5 nTPM
thalamus: 6.3 nTPM
medulla oblongata: 6 nTPM
cerebral cortex: 5.8 nTPM
basal ganglia: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN20 as an antibody target. Whether an autoantibody or antibody against CLDN20 could matter depends on whether native CLDN20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN20 is annotated at the cell surface, where native CLDN20 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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