Seroatlas · Human Serome Atlas

CLDN15

Claudin-15

Also known as: CLD15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56746
Gene: CLDN15
Ensembl: ENSG00000106404
Chromosome: 7
Canonical length: 228 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>P56746|CLDN15
     1  MSMAVETFGF FMATVGLLML GVTLPNSYWR VSTVHGNVIT TNTIFENLWF SCATDSLGVY
    61  NCWEFPSMLA LSGYIQACRA LMITAILLGF LGLLLGIAGL RCTNIGGLEL SRKAKLAATA
   121  GALHILAGIC GMVAISWYAF NITRDFFDPL YPGTKYELGP ALYLGWSASL ISILGGLCLC
   181  SACCCGSDED PAASARRPYQ APVSVMPVAT SDQEGDSSFG KYGRNAYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 244 nTPM

Expression across tissuesHPA

Tissue

duodenum: 244 nTPM
small intestine: 173 nTPM
adipose tissue: 69 nTPM
kidney: 37 nTPM
colon: 24 nTPM
liver: 24 nTPM

Single-cell type

enterocytes: 564 nCPM
paneth cells: 178 nCPM
enteric transient amplifying cells: 147 nCPM
mesothelial cells: 128 nCPM
enteric stem cells: 121 nCPM
gastric progenitor cells: 39 nCPM

Immune cell

memory CD4 T-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

white matter: 29 nTPM
cerebral cortex: 17 nTPM
medulla oblongata: 16 nTPM
pons: 15 nTPM
basal ganglia: 14 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0.02
gnomAD missense Z: 0.67
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN15 as an antibody target. Whether an autoantibody or antibody against CLDN15 could matter depends on whether native CLDN15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN15 is annotated at the cell surface, where native CLDN15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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