CLDN10

Protein identityUniProt · HPA

UniProt accession

P78369

Gene

CLDN10

Ensembl

ENSG00000134873

Chromosome

13

Canonical length

228 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>P78369|CLDN10
     1  MASTASEIIA FMVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYWANLW KACVTDSTGV
    61  SNCKDFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG MKCTKVGGSD KAKAKIACLA
   121  GIVFILSGLC SMTGCSLYAN KITTEFFDPL FVEQKYELGA ALFIGWAGAS LCIIGGVIFC
   181  FSISDNNKTP RYTYNGATSV MSSRTKYHGG EDFKTTNPSK QFDKNAYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

112 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLDN10.

Disease | AllUniProt

Conditions CLDN10 is implicated in, by any mechanism.

• HELIX syndrome (HELIX) MIM:617671

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 53 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• HELIX syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

0.54

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• bicellular tight junction assembly
• calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
• cell adhesion
• monoatomic ion transport
• paracellular transport
• regulation of monoatomic ion transport

Molecular functions

• identical protein binding
• paracellular tight junction channel activity
• structural molecule activity

Cellular components

• bicellular tight junction
• cytoplasm
• plasma membrane
• tight junction

Protein domainsUniProt · Pfam · InterPro

• PMP-22/EMP/MP20/Claudin
• Claudin
• Claudin, conserved site
• PMP-22/EMP/MP20/Claudin family
• Claudin-10

KeywordsUniProt

• Cell junction
• Cell membrane
• Ichthyosis
• Ion transport
• Membrane
• Tight junction
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of CLDN10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CLDN19