Seroatlas · Human Serome Atlas

CIR1

Corepressor interacting with RBPJ 1

Also known as: CIR, CIR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X95
Gene: CIR1
Ensembl: ENSG00000138433
Chromosome: 2
Canonical length: 450 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q86X95|CIR1
     1  MGKSFANFMC KKDFHPASKS NIKKVWMAEQ KISYDKKKQE ELMQQYLKEQ ESYDNRLLMG
    61  DERVKNGLNF MYEAPPGAKK ENKEKEETEG ETEYKFEWQK GAPREKYAKD DMNIRDQPFG
   121  IQVRNVRCIK CHKWGHVNTD RECPLFGLSG INASSVPTDG SGPSMHPSEL IAEMRNSGFA
   181  LKRNVLGRNL TANDPSQEYV ASEGEEDPEV EFLKSLTTKQ KQKLLRKLDR LEKKKKKKDR
   241  KKKKFQKSRS KHKKHKSSSS SSSSSSSSSS TETSESSSES ESNNKEKKIQ RKKRKKNKCS
   301  GHNNSDSEEK DKSKKRKLHE ELSSSHHNRE KAKEKPRFLK HESSREDSKW SHSDSDKKSR
   361  THKHSPEKRG SERKEGSSRS HGREERSRRS RSRSPGSYKQ RETRKRAQRN PGEEQSRRND
   421  SRSHGTDLYR GEKMYREHPG GTHTKVTQRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 66 nTPM
bone marrow: 63 nTPM
epididymis: 41 nTPM
ovary: 34 nTPM
breast: 34 nTPM
spleen: 33 nTPM

Single-cell type

neutrophils: 584 nCPM
oocytes: 580 nCPM
late primary spermatocytes: 560 nCPM
fallopian tube ciliated cells: 286 nCPM
endometrial ciliated cells: 266 nCPM
respiratory ciliated cells: 237 nCPM

Immune cell

neutrophil: 188 nTPM
basophil: 71 nTPM
eosinophil: 56 nTPM
NK-cell: 46 nTPM
memory B-cell: 41 nTPM
naive B-cell: 41 nTPM

Brain region

white matter: 33 nTPM
choroid plexus: 33 nTPM
cerebral cortex: 33 nTPM
cerebellum: 30 nTPM
basal ganglia: 30 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.39
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

CBF1-interacting co-repressor CIR, N-terminal domain
N-terminal domain of CBF1 interacting co-repressor CIR
Corepressor interacting with RBPJ 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIR1 as an antibody target. Whether an autoantibody or antibody against CIR1 could matter depends on whether native CIR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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