Seroatlas · Human Serome Atlas

CIMAP1D

Protein CIMAP1D

Also known as: C19orf19, CMA1D_HUMAN, FLJ40059, ODF3L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3SX64
Gene: CIMAP1D
Ensembl: ENSG00000181781
Chromosome: 19
Canonical length: 289 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Flagellar centriole,Mid piece,Principal piece

OverviewNCBI Gene

Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q3SX64|CIMAP1D
     1  MGTLSCDSTP RLATAPLGRR VTEGQIPETG LRKSCGTATL ENGSGPGLYV LPSTVGFINH
    61  DCTRVASPAY SLVRRPSEAP PQDTSPGPIY FLDPKVTRFG RSCTPAYSMQ GRAKSRGPEV
   121  TPGPGAYSPE KVPPVRHRTP PAFTLGCRLP LKPLDTSAPA PNAYTMPPLW GSQIFTKPSS
   181  PSYTVVGRTP PARPPQDPAE IPGPGQYDSP DANTYRQRLP AFTMLGRPRA PRPLEETPGP
   241  GAHCPEQVTV NKARAPAFSM GIRHSKRAST MAATTPSRPA GHRLPGRCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMAP1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
skeletal muscle: 7.7 nTPM
spinal cord: 0.7 nTPM
spleen: 0.7 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM

Single-cell type

late spermatids: 2,266 nCPM
early spermatids: 253 nCPM
late primary spermatocytes: 34 nCPM
myonuclei: 9.5 nCPM
hepatic stellate cells: 6.5 nCPM
undifferentiated spermatogonia: 5.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.7 nTPM
thalamus: 1.5 nTPM
amygdala: 1.4 nTPM
medulla oblongata: 1.4 nTPM
pons: 1.3 nTPM
white matter: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0.03
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMAP1D as an antibody target. Whether an autoantibody or antibody against CIMAP1D could matter depends on whether native CIMAP1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMAP1D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMAP1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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