Seroatlas · Human Serome Atlas

CIMAP1C

Protein CIMAP1C

Also known as: CMA1C_HUMAN, MGC48986, ODF3L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXM7
Gene
CIMAP1C
Ensembl
ENSG00000182950
Chromosome
15
Canonical length
274 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be active in cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q8IXM7|CIMAP1C
     1  MKLPKGTRSS VYFAQHPEKE PLPSRQEVKQ TPVIMAKIKG PGPAKYLRPS CTGYIDHDIS
    61  MFKAPAYTLH SRHSEKRMVC HSSPGPCYLL DPKITRFGMS SCPQVPMEER ISNLRLNPTL
   121  ASCQYYFEKI HPPGERRAPQ YTFGYRRPYR VMDLNPAPNQ YQMPLLLGPN TPVSRAAPCY
   181  SLASRDKNWF YKEDVAGGPG PTTYARPEPS IYQNRSPTYS MAKRFAYPLD LTPRPGPGSH
   241  EVQQVTVHKP HIPAFTMGIK HSLHLCPLVI DIRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMAP1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • testis: 22 nTPM
  • choroid plexus: 2.8 nTPM
  • gallbladder: 2.4 nTPM
  • skin: 1.8 nTPM
  • stomach: 1.6 nTPM
  • lung: 1.5 nTPM

Single-cell type

  • late primary spermatocytes: 118 nCPM
  • early spermatids: 87 nCPM
  • epididymal basal cells: 18 nCPM
  • epididymal efferent duct ciliated cells: 14 nCPM
  • fallopian tube ciliated cells: 8.4 nCPM
  • late spermatids: 6.2 nCPM

Immune cell

  • myeloid DC: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 3.7 nTPM
  • midbrain: 2 nTPM
  • choroid plexus: 1.9 nTPM
  • cerebral cortex: 1.8 nTPM
  • basal ganglia: 1.6 nTPM
  • hypothalamus: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMAP1C as an antibody target. Whether an autoantibody or antibody against CIMAP1C could matter depends on whether native CIMAP1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMAP1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMAP1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIMAP1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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