Seroatlas · Human Serome Atlas

CIMAP1B

Ciliary microtubule associated protein 1B

Also known as: CMA1B_HUMAN, FAP123, ODF3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MYP8
Gene: CIMAP1B
Ensembl: ENSG00000177989
Chromosome: 22
Canonical length: 253 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in motile cilium. Predicted to be active in cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>A8MYP8|CIMAP1B
     1  MGSDAWVGLW RPHRPRGPIA AHYGGPGPKY KLPPNTGYAL HDPSRPRAPA FTFGARFPTQ
    61  QTTCGPGPGH LVPARMTVRG TDGAPAYSIY GRPRRSAPFL TPGPGRYFPE RAGNATYPSA
   121  PRHTIAPRNW GVQAEQQSPG PAAYTVPSLL GPRVIGKVSA PTCSIYGRRA AGSFFEDLSK
   181  TPGPCAYQVV SPGVYKSRAP QFTILARTSL PQDNTRKPGP AAYNVDQHRK PRGWSFGIRH
   241  SDYLAPLVTD ADN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIMAP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 75 nTPM
salivary gland: 47 nTPM
fallopian tube: 47 nTPM
lung: 36 nTPM
appendix: 34 nTPM
spleen: 27 nTPM

Single-cell type

late spermatids: 1,271 nCPM
fallopian tube ciliated cells: 1,050 nCPM
epididymal efferent duct ciliated cells: 829 nCPM
respiratory ciliated cells: 774 nCPM
endometrial ciliated cells: 491 nCPM
early spermatids: 182 nCPM

Immune cell

classical monocyte: 94 nTPM
intermediate monocyte: 82 nTPM
neutrophil: 66 nTPM
non-classical monocyte: 58 nTPM
myeloid DC: 57 nTPM
total PBMC: 29 nTPM

Brain region

medulla oblongata: 77 nTPM
midbrain: 69 nTPM
choroid plexus: 42 nTPM
spinal cord: 35 nTPM
pons: 33 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIMAP1B as an antibody target. Whether an autoantibody or antibody against CIMAP1B could matter depends on whether native CIMAP1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIMAP1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIMAP1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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