CIMAP1A
Ciliary microtubule associated protein 1A
Also known as: CMA1A_HUMAN, CT135, hSHIPPO, ODF3, SHIPPO1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96PU9
- Gene
- CIMAP1A
- Ensembl
- ENSG00000177947
- Chromosome
- 11
- Canonical length
- 254 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mid piece,Principal piece,End piece
OverviewNCBI Gene
ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]
Canonical amino-acid sequenceUniProt
254 residues, UniProt reviewed canonical sequence.
>Q96PU9|CIMAP1A
1 MTEEVWMGTW RPHRPRGPIM ALYSSPGPKY LIPPTTGFMK HTPTKLRAPA YSFRGAPMLL
61 AENCSPGPRY NVNPKILRTG KDLGPAYSIL GRYQTKTMLT PGPGDYFPEK STKYVFDSAP
121 SHSISARTKA FRVDSTPGPA AYMLPMVMGP NTVGKASQPS FSIKGRSKLG GFSDDLHKTP
181 GPAAYRQTDV RVTKFKAPQY TMAARVEPPG DKTLKPGPGA HSPEKVTLTK PCAPVVTFGI
241 KHSDYMTPLL VDVELocalizationUniProt · AlphaFold · HPA
Whether an antibody against CIMAP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 9 nTPM
Expression across tissuesHPA
Tissue
- testis: 9 nTPM
- retina: 0.4 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- early spermatids: 90 nCPM
- late primary spermatocytes: 61 nCPM
- late spermatids: 24 nCPM
- thymic myoid cells: 1.4 nCPM
- sertoli cells: 0.6 nCPM
- cardiomyocytes: 0.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.7 nTPM
- cerebral cortex: 0.6 nTPM
- medulla oblongata: 0.6 nTPM
- white matter: 0.5 nTPM
- basal ganglia: 0.4 nTPM
- midbrain: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.77
- gnomAD pLI
- 0.15
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CIMAP1A as an antibody target. Whether an autoantibody or antibody against CIMAP1A could matter depends on whether native CIMAP1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CIMAP1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CIMAP1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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