Seroatlas · Human Serome Atlas

CHRNA6

Neuronal acetylcholine receptor subunit alpha-6

Also known as: ACHA6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15825
Gene
CHRNA6
Ensembl
ENSG00000147434
Chromosome
8
Canonical length
494 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>Q15825|CHRNA6
     1  MLTSKGQGFL HGGLCLWLCV FTPFFKGCVG CATEERLFHK LFSHYNQFIR PVENVSDPVT
    61  VHFEVAITQL ANVDEVNQIM ETNLWLRHIW NDYKLRWDPM EYDGIETLRV PADKIWKPDI
   121  VLYNNAVGDF QVEGKTKALL KYNGMITWTP PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT
   181  YDKAEIDLLI IGSKVDMNDF WENSEWEIID ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP
   241  MFYTINLIIP CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVV
   301  PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPTTHTMPRW VKTVFLKLLP QVLLMRWPLD
   361  KTRGTGSDAV PRGLARRPAK GKLASHGEPR HLKECFHCHK SNELATSKRR LSHQPLQWVV
   421  ENSEHSPEVE DVINSVQFIA ENMKSHNETK EVEDDWKYVA MVVDRVFLWV FIIVCVFGTA
   481  GLFLQPLLGN TGKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRNA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
3 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3 nTPM
  • cerebellum: 0.8 nTPM
  • midbrain: 0.8 nTPM
  • choroid plexus: 0.5 nTPM
  • thymus: 0.5 nTPM
  • tonsil: 0.4 nTPM

Single-cell type

  • retinal amacrine cells: 30 nCPM
  • retinal ganglion cells: 23 nCPM
  • adrenal medulla cells: 11 nCPM
  • breast lactating cells: 5.4 nCPM
  • brain excitatory neurons: 3.8 nCPM
  • late spermatids: 3.3 nCPM

Immune cell

  • T-reg: 0.8 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 20 nTPM
  • thalamus: 8.5 nTPM
  • midbrain: 7.1 nTPM
  • medulla oblongata: 4.7 nTPM
  • choroid plexus: 3 nTPM
  • pons: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHRNA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRNA6 as an antibody target. Whether an autoantibody or antibody against CHRNA6 could matter depends on whether native CHRNA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRNA6 is annotated at the cell surface, where native CHRNA6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CHRNA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHRNA6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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