Seroatlas · Human Serome Atlas

CHRNA10

Neuronal acetylcholine receptor subunit alpha-10

Also known as: ACH10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZZ6
Gene
CHRNA10
Ensembl
ENSG00000129749
Chromosome
11
Canonical length
450 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity; serotonin-gated monoatomic cation channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in cholinergic synapse; neuron projection; and postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q9GZZ6|CHRNA10
     1  MGLRSHHLSL GLLLLFLLPA ECLGAEGRLA LKLFRDLFAN YTSALRPVAD TDQTLNVTLE
    61  VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LRWDPNAYGG LDAIRIPSSL VWRPDIVLYN
   121  KADAQPPGSA STNVVLRHDG AVRWDAPAIT RSSCRVDVAA FPFDAQHCGL TFGSWTHGGH
   181  QLDVRPRGAA ASLADFVENV EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV
   241  CNLLLPCVLI SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLLLAESMP PAESVPLIGK
   301  YYMATMTMVT FSTALTILIM NLHYCGPSVR PVPAWARALL LGHLARGLCV RERGEPCGQS
   361  RPPELSPSPQ SPEGGAGPPA GPCHEPRCLC RQEALLHHVA TIANTFRSHR AAQRCHEDWK
   421  RLARVMDRFF LAIFFSMALV MSLLVLVQAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRNA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 45 nTPM
  • cerebellum: 2.1 nTPM
  • spleen: 1.8 nTPM
  • liver: 1.6 nTPM
  • choroid plexus: 1.5 nTPM
  • kidney: 1.4 nTPM

Single-cell type

  • neutrophils: 9.5 nCPM
  • endometrial glandular cells: 5.3 nCPM
  • thymic myoid cells: 4.1 nCPM
  • paneth cells: 3.9 nCPM
  • endometrial luminal cells: 3.8 nCPM
  • endometrial secretory cells: 3.6 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 2.3 nTPM
  • cerebellum: 2 nTPM
  • amygdala: 1.5 nTPM
  • choroid plexus: 1.5 nTPM
  • pons: 1.4 nTPM
  • basal ganglia: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRNA10 as an antibody target. Whether an autoantibody or antibody against CHRNA10 could matter depends on whether native CHRNA10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRNA10 is annotated at the cell surface, where native CHRNA10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CHRNA10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHRNA10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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