Seroatlas · Human Serome Atlas

CHRFAM7A

CHRNA7-FAM7A fusion protein

Also known as: CHRNA7-DR1, CRFM7_HUMAN, D-10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q494W8
Gene: CHRFAM7A
Ensembl: ENSG00000166664
Chromosome: 15
Canonical length: 412 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q494W8|CHRFAM7A
     1  MQKYCIYQHF QFQLLIQHLW IAANCDIADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC
    61  YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG IPGKRSERFY
   121  ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL VFLLPADSGE KISLGITVLL
   181  SLTVFMLLVA EIMPATSDSV PLIAQYFAST MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW
   241  TRVILLNWCA WFLRMKRPGE DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR
   301  GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ
   361  DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD FA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRFAM7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 5.3 nTPM
bone marrow: 4.1 nTPM
testis: 2.5 nTPM
blood vessel: 2.3 nTPM
thyroid gland: 1.4 nTPM
heart muscle: 1.2 nTPM

Single-cell type

retinal horizontal cells: 6 nCPM
podocytes: 5.9 nCPM
distal convoluted tubule cells: 5.4 nCPM
renal connecting tubule cells: 5.3 nCPM
renal collecting duct principal cells: 4.6 nCPM
loop of henle epithelial cells: 4.1 nCPM

Immune cell

eosinophil: 2.9 nTPM
myeloid DC: 1.4 nTPM
classical monocyte: 0.9 nTPM
NK-cell: 0.4 nTPM
intermediate monocyte: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM

Brain region

midbrain: 3.5 nTPM
medulla oblongata: 3.1 nTPM
pons: 2.8 nTPM
cerebral cortex: 1.8 nTPM
hypothalamus: 1.7 nTPM
spinal cord: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRFAM7A as an antibody target. Whether an autoantibody or antibody against CHRFAM7A could matter depends on whether native CHRFAM7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRFAM7A is annotated at the cell surface, where native CHRFAM7A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CHRFAM7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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