CHRAC1
Chromatin accessibility complex protein 1
Also known as: CHRAC15, CHRC1_HUMAN, YCL1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NRG0
- Gene
- CHRAC1
- Ensembl
- ENSG00000104472
- Chromosome
- 8
- Canonical length
- 131 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Canonical amino-acid sequenceUniProt
131 residues, UniProt reviewed canonical sequence.
>Q9NRG0|CHRAC1
1 MADVVVGKDK GGEQRLISLP LSRIRVIMKS SPEVSSINQE ALVLTAKATE LFVQCLATYS
61 YRHGSGKEKK VLTYSDLANT AQQSETFQFL ADILPKKILA SKYLKMLKEE KREEDEENDN
121 DNESDHDEAD SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CHRAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 26 nTPM
- skeletal muscle: 26 nTPM
- tonsil: 25 nTPM
- tongue: 24 nTPM
- lymph node: 22 nTPM
- blood vessel: 22 nTPM
Single-cell type
- early primary spermatocytes: 92 nCPM
- gastric progenitor cells: 73 nCPM
- megakaryocyte progenitors: 69 nCPM
- megakaryocytes: 62 nCPM
- extravillous trophoblasts: 61 nCPM
- erythrocyte progenitors: 60 nCPM
Immune cell
- non-classical monocyte: 30 nTPM
- intermediate monocyte: 27 nTPM
- eosinophil: 26 nTPM
- neutrophil: 24 nTPM
- naive B-cell: 24 nTPM
- plasmacytoid DC: 23 nTPM
Brain region
- white matter: 32 nTPM
- medulla oblongata: 26 nTPM
- basal ganglia: 25 nTPM
- midbrain: 23 nTPM
- thalamus: 20 nTPM
- pons: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.49
- gnomAD pLI
- 0.07
- gnomAD missense Z
- 0.35
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 20% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CHRAC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CHRAC1 as an antibody target. Whether an autoantibody or antibody against CHRAC1 could matter depends on whether native CHRAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CHRAC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CHRAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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