CHMP4BP1
Putative charged multivesicular body protein 4B-like protein CHMP4BP1
Also known as: CHM4P_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for CHMP4BP1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
171 residues, UniProt reviewed canonical sequence.
>P59074|CHMP4BP1
1 MLSKKQEFLE KKIEQRHGTK NKPAALQALK RKKRYEKQLA QIDGTLSTIE FQQQALENAN
61 TNTEVLKNMG SAAKAKKAAH DNMDIDKVDE LMQDIADQQE LGEEISTAIS KPVGFGEKSD
121 EDELMAELEE LEQEEPDKNL LEVSGPETVP LPNVPSIALP SKPAKKRKTT TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CHMP4BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
OntologyGO
Biological processes
- autophagosome maturation
- late endosome to lysosome transport
- late endosome to vacuole transport via multivesicular body sorting pathway
- midbody abscission
- mitotic metaphase chromosome alignment
- nuclear membrane reassembly
- plasma membrane repair
- regulation of mitotic spindle assembly
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- vesicle budding from membrane
- viral budding from plasma membrane
- viral budding via host ESCRT complex
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CHMP4BP1 as an antibody target. Whether an autoantibody or antibody against CHMP4BP1 could matter depends on whether native CHMP4BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CHMP4BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CHMP4BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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