Seroatlas · Human Serome Atlas

CHGB

Secretogranin-1

Also known as: SCG1, SCG1_HUMAN, SgI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P05060
Gene: CHGB
Ensembl: ENSG00000089199
Chromosome: 20
Canonical length: 677 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>P05060|CHGB
     1  MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA PPITPECRQV
    61  LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS RGEAGAPGEE DIQGPTKADT
   121  EKWAEGGGHS RERADEPQWS LYPSDSQVSE EVKTRHSEKS QREDEEEEEG ENYQKGERGE
   181  DSSEEKHLEE PGETQNAFLN ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG
   241  EETGSQENHP QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP
   301  SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG VQAPEDLEWE
   361  RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG YGEESEEERG LEPGKGRHHR
   421  GRGGEPRAYF MSDTREEKRF LGEGHHRVQE NQMDKARRHP QGAWKELDRN YLNYGEEGAP
   481  GKWQQQGDLQ DTKENREEAR FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD
   541  NMNDNFLEGE EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ
   601  YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE DEKKELENLA
   661  AMDLELQKIA EKFSQRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHGB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 3,273 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 3,273 nTPM
pituitary gland: 1,393 nTPM
cerebellum: 664 nTPM
hypothalamus: 127 nTPM
stomach: 126 nTPM
cerebral cortex: 98 nTPM

Single-cell type

gonadotrophs: 4,713 nCPM
pancreatic islet cells: 3,423 nCPM
adrenal medulla cells: 2,904 nCPM
neuroendocrine cells: 1,087 nCPM
lactotrophs: 957 nCPM
somatotrophs: 937 nCPM

Immune cell

memory CD4 T-cell: 0.5 nTPM
myeloid DC: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

pons: 471 nTPM
cerebellum: 343 nTPM
hippocampal formation: 277 nTPM
midbrain: 274 nTPM
hypothalamus: 265 nTPM
cerebral cortex: 259 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHGB.

Disease | ImmuneIEDB

Conditions an epitope on CHGB was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

hormone activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHGB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHGB as an antibody target. Whether an autoantibody or antibody against CHGB could matter depends on whether native CHGB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHGB is annotated as secreted, so native CHGB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CHGB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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