Seroatlas · Human Serome Atlas

CEP95

Centrosomal protein of 95 kDa

Also known as: CCDC45, CEP95_HUMAN, DKFZp667E1824

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GE4
Gene
CEP95
Ensembl
ENSG00000258890
Chromosome
17
Canonical length
821 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Centriolar satellite,Cytosol

OverviewNCBI Gene

Located in centrosome and spindle pole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

821 residues, UniProt reviewed canonical sequence.

>Q96GE4|CEP95
     1  MAGSDAEWVT IANNLLFKCH IHLRIHELQD CDANVFIALY QSILGEKVPD LIVIPRSQED
    61  DAHNVQAVID SLALDYLQVS LSHITGENIV KGDKESIKNL LEIFDGLLEY LTERISETSH
   121  EKSETEQYFK ESDRGERLEE PESTKESKSS WKRVSFGRCS LSSEMLGPSW DGDEAESTGE
   181  IIRLGDTAHT FSLRSNGAQC PNEMLSKKAL ASPSSKSHED MLYPPSVLSK SRTSFVEDTE
   241  TLSVSGIPNA RKLGEPIRAA IPLHPPYHPS EPRAPCPIGK EYLHSSHCSP AVNSTGEHTE
   301  FSGDLDDGLF LISKLPKGSK WEVYPAQVQG PRTRKPPKGK RNENRATASS CNSPFPQRPR
   361  KRLTEQELHD VSEKLSQRLS ELDWMLKSAL GDRIKEKTDH KEENTGNEEV EDGTEETLSQ
   421  HSDGIVEYGP KKSRPGLSMR RKPPYRSHSL SPSPVNKHKQ FHLERKRQRK PRETDVRQFQ
   481  AQAFTEAFER ELRRHKVQEN IGPLRIHEKE EETEKIYRGE AVRKGTPECS QPWKIYSRKT
   541  TTQSLRGGLP KPNKAVPMKV SEHSLLPLML EQFPFLYVSG PTLSKMWKQQ IAQVEQLKKE
   601  ACRENRSKKK LQDEIEEALR RHDLLTTLVK KEYEHNKRLQ DFKDCIRRQR LTQSKIKENR
   661  QQIVRARKYY DDYRVQLCAK MMRMRTREEM IFKKLFEEGL NIQKQRLRDL RNYAKEKRDE
   721  QRRRHQDELD SMENYYKDQF SLLAEAISQE HQELKAREKS QAQTLHKVKR ELRSKMEKEI
   781  QQLQDMITQN DDDVFFRELE AERFRSRLQL ASFQYSKSPS L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP95 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 40 nTPM
  • retina: 37 nTPM
  • endometrium: 22 nTPM
  • ovary: 22 nTPM
  • skin: 22 nTPM
  • choroid plexus: 21 nTPM

Single-cell type

  • ependymal cells: 147 nCPM
  • myonuclei: 146 nCPM
  • rod photoreceptor cells: 143 nCPM
  • distal convoluted tubule cells: 124 nCPM
  • choroid plexus epithelial cells: 124 nCPM
  • endometrial ciliated cells: 119 nCPM

Immune cell

  • MAIT T-cell: 7.1 nTPM
  • naive CD4 T-cell: 6 nTPM
  • memory CD8 T-cell: 4.3 nTPM
  • naive CD8 T-cell: 4 nTPM
  • memory CD4 T-cell: 3.7 nTPM
  • naive B-cell: 3.7 nTPM

Brain region

  • cerebellum: 50 nTPM
  • white matter: 40 nTPM
  • choroid plexus: 40 nTPM
  • midbrain: 31 nTPM
  • medulla oblongata: 30 nTPM
  • cerebral cortex: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
-0.71
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centrosomal protein of 95kDa
  • Domain of unknown function DUF5745
  • Domain of unknown function (DUF5745)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP95 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP95 as an antibody target. Whether an autoantibody or antibody against CEP95 could matter depends on whether native CEP95 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP95 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP95 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP95. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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